Orthogonal translation components for the in vivo incorporation of unnatural amino acids

Dan Groff (Inventor), James Turner (Inventor), Alexander Deiters (Inventor), Meng-Lin Tsao (Inventor), Mohammad R Seyedsayamdost (Inventor), Jianming Xie (Inventor), Huaqiang Zeng (Inventor), Daniel Summerer (Inventor), Ning Wu (Inventor), Jiangyun Wang (Inventor), Peter Schultz (Inventor), Lital Alfonta (Inventor), Jonathan R Chittuluru (Inventor)

Research output: Patent

Abstract

The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.

Original languageEnglish
Patent numberAU2011204773
IPCC12N 15/ 00 A I
Priority date14/07/11
StatePublished - 4 Aug 2011

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