Outcome of children after traumatic brain injury-first results of the creactkids study (on behalf of the creactive consortium)

Isaac Lazar, Or Abraham Duek, Vera Knyazer, Eitan Neeman, Sharon Naparstek, Andrea Berger, Moshe Lachish, Aviv Goldbart, Asher Tal, IRCCS Negri, IRCCS Negri, IRCCS Negri

Research output: Contribution to journalMeeting Abstractpeer-review


CREACTIVE multinational project follows patients with moderate-to-severe traumatic brain injury (TBI), as part of the global InTBIR initiative. Patients outcome are measured in terms of injury-related disability and quality of life at 6 months post-injury. CREACTKids is the paediatric sub-study which is led by a team from Ben Gurion University of the Negev in Israel. The Pediatric Intensive care unit (PICU) at Soroka University Medical Center is the first to fully implement the study tools and we present our methodology and the centre’s results. Materials and Methods: Common Data Elements endorsed by InTBIR are collected, along with items required to develop a sensitive prognostic model. Clinical data is collected via computerized software built and maintained by the CREACTIVE study centre situated in the Department of Clinical Epidemiology of Mario Negri institute, Ranica, Italy. Patients outcome are followed-up with separate Toolbox built for CREACTKids study. The toolbox assesses impairment and disability in sleep, behavioural, emotional and neurocognitive dimensions and is distributed via the computerized software using both questionnaires and computer-based neurocognitive tasks on designated touch screen. We present the first CREACTKids results from our PICU: Two-year descriptive results, Toolbox assessment pilot study and TBI patients’ outcome assessment. Results: Descriptive data—1280 patients were admitted to our PICU during 2014–2015, 105 (8.2%) due to TBI. Mean age was 5.1 years, 68% were male. 95% came from the emergency room; 94% came from our hospital. Co-morbidity from other diseases was rare. Most head injuries were closed (84%) from low energy falls or traffic accidents; 58% of cases had focal injury, half of them with subarachnoid haemorrhage. 7.5% had diffuse injury. Overall ICU mortality was 2.8% and average length of PICU stay was 2.5 days [median 1 day (1–23)]. Toolbox pilot study—the aim was to assess the feasibility of our toolbox to be submitted and complete follow-up in diverse PICU patients. 52 PICU patients were approached and 49 consented to participate. 36 (73%) completed phone call follow-up and 18 arrived to the face-to-face meeting. We concluded that our Tool-Box is a practical and easy-to-distribute tool. CTRACTKids 6-month follow-up outcome preliminary results—Recruitment rate was 50% of TBI parents consenting to participate in the study; of them 86% completed the follow-up procedure. Half of the patients who completed the procedure presented symptoms of post-traumatic stress disorder (PTSD) in mild-to-severe manifestation. More than 60% of the patients presented sleep disorder that were not present before the injury. All but three patients completed the computer tasks. All patients passed a short physical examination, physical disability was rare. Conclusions: We present the first paediatric results of our CREACTKids study which brings important information on post-TBI outcome in children.
Original languageEnglish
Pages (from-to)972-972
JournalBrain Injury
Issue number6-7
StatePublished - Mar 2017


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