Outcome of polyarteritis nodosa and churg‐strauss syndrome

Mahmoud Abu‐Shakra, Hugh Smythe, Jody Lewtas, Elizabeth Badley, Deborah Weber, Edward Keystone

Research output: Contribution to journalArticlepeer-review

111 Scopus citations


Objective. To compare outcome in patients with polyarteritis nodosa (PAN) and patients with Churg‐Strauss syndrome (CSS) followed up at a single center. Methods. A retrospective data review of 13 patients with PAN and 12 patients with CSS who were followed up at a vasculitis clinic. Outcome measures included a global damage index, disability and pain dimensions of the Health Assessment Questionnaire, and mortality rate. Results. Compared with patients with CSS, patients with PAN had a significantly higher mean damage index score (5.15 versus 2.42; P = 0.011), a higher disability score (1.09 versus 0.16; P = 0.007), and a higher pain score (1.04 versus 0.01; P = 0.017). Patients with PAN had more relapses (relative risk = 5.07; P < 0.000) and a higher mortality rate (31%) compared with patients with CSS (8%). Conclusion. PAN and CSS differ in their morbidity and mortality; therefore, they should be considered as distinct clinical entities.

Original languageEnglish
Pages (from-to)1798-1803
Number of pages6
JournalArthritis and Rheumatology
Issue number12
StatePublished - 1 Jan 1994
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)


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