Outcomes of ovarian stimulation and fertility preservation in breast cancer patients with different hormonal receptor profiles

Jacques Balayla, Togas Tulandi, William Buckett, Hananel Holzer, Naama Steiner, Guy Shrem, Alexander Volodarsky-Perel

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Purpose: To evaluate fertility preservation outcomes in breast cancer women with different hormonal receptor profiles before oncological treatment. Methods: The study population included women with a diagnosis of breast cancer who underwent fertility preservation from 2009 until 2018 at a university-affiliated tertiary hospital. Stimulation parameters and fertility preservation outcomes were compared among the following receptor-specific profile groups: (1) estrogen receptor positive (ER+) versus estrogen receptor negative (ER−), (2) triple-negative breast cancer (TNBC) versus estrogen and progesterone receptor positive (ER+/PR+), and (3) TNBC versus non-TNBC. Primary outcome was the total number of mature oocytes. Secondary outcomes included the number of retrieved oocytes, the peak estradiol level, and the number of follicles > 14 mm on the final oocyte maturation trigger day. Results: A total of 155 cycles were included in the final analysis. These were divided into the exposure groups of ER+ (n = 97), ER− (n = 58), ER+/PR+ (n = 85), TNBC (n = 57), and non-TNBC (n = 98). Cycle outcomes revealed similar number of retrieved oocytes and follicles > 14 mm on the trigger day. Women with TNBC had significantly lower number of mature oocytes compared with those with ER + PR+ (7 (5–11) versus 9 (7–15); p = 0.02) and non-TNBC (7 (5–11) versus 9 (7–16); p = 0.01) status. Triple-negative breast cancer profile was associated with a significant reduction in the chance of developing over 10 mature oocytes (OR 0.41; 95% CI 0.19–0.92). Conclusion: Among the different hormonal receptor profiles in breast cancer, the TNBC subtype has a negative effect on fertility preservation outcomes.

Original languageEnglish
Pages (from-to)913-921
Number of pages9
JournalJournal of Assisted Reproduction and Genetics
Volume37
Issue number4
DOIs
StatePublished - 1 Apr 2020
Externally publishedYes

Keywords

  • Estrogen receptor
  • Fertility preservation
  • Number of oocytes
  • Progesterone receptor
  • Triple-negative breast cancer

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)

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