Ovarian hyperstimulation syndrome following GnRH agonist trigger—think ectopic

Raoul Orvieto, Valeria Stella Vanni

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Purpose: This study aims to report a case of ovarian hyperstimulation syndrome (OHSS) following GnRH agonist trigger for final follicular maturation. Methods: This study is a retrospective chart review. Results: We report the first case of OHSS following GnRH agonist trigger for final follicular maturation and freeze-all, masking extrauterine pregnancy (EUP). The present case report elucidates the feasibility of stimulating and recruiting ovarian follicles yielding mature oocytes during early pregnancy and the ability of GnRH agonist to trigger final follicular maturation during pregnancy, in the presence of high progesterone and hCG levels. Conclusions: Since OHSS almost always develops after hCG administration or in early pregnancy, its occurrence following GnRH agonist trigger should alert physician to search for either an inadvertent administration of exogenous hCG, or the endogenous secretion of hCG by pregnancy, e.g. EUP, or as part of a paraneoplastic syndrome.

Original languageEnglish
Pages (from-to)1161-1165
Number of pages5
JournalJournal of Assisted Reproduction and Genetics
Volume34
Issue number9
DOIs
StatePublished - 1 Sep 2017
Externally publishedYes

Keywords

  • EUP
  • GnRH agonist
  • OHSS
  • Trigger

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