Abstract
In an attempt to examine whether body mass index (BMI) may influence IVF outcome in polycystic ovary syndrome (PCOS) patients undergoing ovarian stimulation with either gonadotrophin-releasing hormone (GnRH)-agonist (agonist group) or antagonist (antagonist group), 100 IVF cycles were studied: 35 in the agonist and 65 in the antagonist groups. In both agonist and antagonist groups, patients with BMI ≤ 25 kg/m2 had a significantly higher fertilization rate compared with patients with BMI > 25 kg/m2 (P < 0.02 and P < 0.01, respectively). Lean patients (BMI ≤ 25) undergoing ovarian stimulation using the GnRH-agonist, demonstrated the highest pregnancy rate. In conclusion, in this series of PCOS patients undergoing IVF-embryo transfer cycles, ovarian stimulation utilizing the midluteal long GnRH-agonist suppressive protocol yielded a higher pregnancy rate in lean patients, probably due to its ability to lower the high basal LH milieu and its detrimental effect on oocyte quality and implantation potential.
Original language | English |
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Pages (from-to) | 333-336 |
Number of pages | 4 |
Journal | Reproductive BioMedicine Online |
Volume | 18 |
Issue number | 3 |
DOIs | |
State | Published - 1 Jan 2009 |
Keywords
- Body mass index
- GnRH agonist
- GnRH antagonist
- IVF outcome
- PCOS
- Pregnancy
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology
- Developmental Biology