Overexpression of the mitochondrial anti-viral signaling protein, MAVS, in cancers is associated with cell survival and inflammation

Sweta Trishna, Avia Lavon, Anna Shteinfer-Kuzmine, Avis Dafa-Berger, Varda Shoshan-Barmatz

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Mitochondrial anti-viral signaling protein (MAVS) plays an important role in host defense against viral infection via coordinating the activation of NF-κB and interferon regulatory factors. The mitochondrial-bound form of MAVS is essential for its anti-viral innate immunity. Recently, tumor cells were proposed to mimic a viral infection by activating RNA-sensing pattern recognition receptors. Here, we demonstrate that MAVS is overexpressed in a panel of viral non-infected cancer cell lines and patient-derived tumors, including lung, liver, bladder, and cervical cancers, and we studied its role in cancer. Silencing MAVS expression reduced cell proliferation and the expression and nuclear translocation of proteins associated with transcriptional regulation, inflammation, and immunity. MAVS depletion reduced expression of the inflammasome components and inhibited its activation/assembly. Moreover, MAVS directly interacts with the mitochondrial protein VDAC1, decreasing its conductance, and we identified the VDAC1 binding site in MAVS. Our findings suggest that MAVS depletion, by reducing cancer cell proliferation and inflammation, represents a new target for cancer therapy.

Original languageEnglish
Pages (from-to)713-732
Number of pages20
JournalMolecular Therapy Nucleic Acids
Volume33
DOIs
StatePublished - 12 Sep 2023

Keywords

  • cancer
  • cell proliferation
  • inflammation
  • MAVS
  • mitochondria
  • MT: Non-coding RNAs
  • siRNA
  • VISA

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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