Overlap among dendrites in neuronal networks is a designed entity onto which functional topology is coded

Danny Baranes

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Information processing in the brain is performed by propagating data through an array of neuronal networks, each having unique structural and topological architectures. However, the mechanisms that specify these architectures are not well understood. We found that neuronal networks in vitro determine the pattern and strength of their connectivity by designing the way dendrites overlap. The branches of neighboring dendrites converge in a collective and ordered fashion, leading to a network configuration that enables axons to innervate multiple and remote dendrites using short wiring lengths. In addition, the convergence sites are associated with synaptic clusters of higher density and strength than found elsewhere, leading to patchy distribution of synaptic strength in the network. Thus, controlled design of the overlap among dendrites patterns and strengthens neuronal connectivity in neuronal networks.

Original languageEnglish
Title of host publicationIntegral Biomathics
Subtitle of host publicationTracing the Road to Reality
PublisherSpringer Berlin Heidelberg
Pages17-27
Number of pages11
ISBN (Electronic)9783642281112
ISBN (Print)9783642281105
DOIs
StatePublished - 1 Jan 2012
Externally publishedYes

Keywords

  • Dendro-dendritic contact
  • Neuronal networks
  • Synaptic strength

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