Oxidative stress as determined by glutathione (GSH) concentrations in venous cord blood in elective cesarean delivery versus uncomplicated vaginal delivery

Orit Paamoni-Keren, Tali Silberstein, Ariela Burg, Iris Raz, Moshe Mazor, Oshra Saphier

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Objective: To determine whether neonates are subject to oxidative stress by the labor process and the mode of delivery by measuring glutathione (GSH) concentrations in umbilical cord venous blood. Study design: Forty-eight women with singleton term pregnancies were prospectively recruited and classified as follows: 26 women had a spontaneous uncomplicated vaginal delivery (VD), and 22 women had an elective cesarean delivery (CD). GSH concentration in umbilical venous blood samples was determined by a spectroscopic method. Results: Umbilical cord venous blood GSH levels were significantly lower in the elective CD group than in the VD group (2.2 and 2.7 mM, respectively, P = 0.0003). There was a significantly negative correlation between cord blood pO2 and GSH levels; however, the negative correlation was significantly higher in the elective CD group (P < 0.05). Conclusion: Neonates delivered by CD were exposed to a higher oxidative stress as determined by GSH levels compared to those who had an uncomplicated VD.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalArchives of Gynecology and Obstetrics
Volume276
Issue number1
DOIs
StatePublished - 1 Jan 2007
Externally publishedYes

Keywords

  • Elective cesarean delivery
  • Glutathione
  • Oxidative stress
  • Uncomplicated vaginal delivery

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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