Abstract
A mild Oxone® mediated reaction for direct regioselective C−H selenylation and thiocyanation of pyrazolo[1,5-a]pyrimidines is established at ambient temperature. This practical and efficient methodology employs Oxone® as a user friendly, green, non-toxic and cheap reagent to facilitate selenylation and thiocyanation at room temperature. The present method offers high regioselectivity, broad substrate scope, mild conditions and excellent yields. Further, this eco-friendly approach could easily be extended for mild C−H selenylation and thiocyanation of other heterocycles. Mechanistic studies indicate that the reaction occurs through electrophilic substitution mechanism via generation of an electrophilic chalcogen species.
Original language | English |
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Article number | e202304815 |
Journal | ChemistrySelect |
Volume | 9 |
Issue number | 1 |
DOIs | |
State | Published - 8 Jan 2024 |
Externally published | Yes |
Keywords
- Chalcogenation
- C−H functionalization
- Heterocycles
- Pyrazolo[1,5-a]pyrimidines
- Regioselective
ASJC Scopus subject areas
- General Chemistry