P25.01: Obstetric characteristics and pregnancy outcome of fetuses affected with either isolated central nervous system malformations or isolated chromosomal abnormalities at term

Objectives
To determine whether pregnancies with a fetus affected with either chromosomal abnormalities or central nervous system (CNS) malformations are prone to complications during pregnancy and delivery at term.
Methods
320 singelton pregnancies with isolated CNS malformations and 133 singelton pregnancies with isolated chromosomal abnormalities that delivered at term, were compared with 149, 112 singelton term births without any known congenital anomalies. Exclusion criteria were: births with other congenital.
Results
The ratio of general anesthesia was 25% in the CNS malformation group (RR 2.617 CI 2.031–3.372), 25.6% in the chromosomal abnormality group (RR 2.696 CI 1.825–3.982) and 11.3% in the control group (P < 0.001). There was nearly a double rate of Cesarean sections (CS) in both study groups 21.5% in the CNS malformation group (RR 1.999 CI 1.53–2.61), 20.3% in the chromosomal abnormality group (RR 1.852 CI 1.214–2.827), and 12% in the control group (P < 0.001). In logistic regression model, a presence of a malformation was not an independent risk factor for CS, however indirect causes such as malpresentation (22.16 OR) and non-reassuring fetal heart rate monitor (39.1) were independently associated with CS.
Conclusions
These Pregnancies are associated with a higher rate of Cesarean section and general anesthesia.