p27kip1 expression in non-small cell lung cancer is not an independent prognostic factor

Netta Sion-Vardy, Janna Freedman, Irena Lazarov, Arkady Bolotin, Samuel Ariad

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations

    Abstract

    Background: p27Kip1 (p27) plays an important role in cancer cell cycle regulation. Recent evidence however, suggests that p27 may function as an oncogene rather than a tumour suppressor gene. Patients and Methods: Ninety-two patients with previously untreated non-small cell lung cancer (NSCLC) were studied for the association between the immunohistochemical localization of p27 through a semi-quantitative method and time-to-progression (TTP) and overall survival (OS). Results: The relationship between p27 H-Score and both TTP and OS was polynomial. Short TTP in patients with metastasis or whose tumors progressed during the eight-month period after diagnosis was statistically associated with overexpression of PIRH2 (p<0.001). In patients whose tumours progressed later, long TTP was associated with NSCLC of the non-adenocarcinoma type (p=0.027), p27 H-Score (p=0.032) and well-differentiated adenocarcinoma (p=0.047). None of the parameters correlated with duration of OS. Conclusions: This study showed that p27 H-Score may not appear to be an independent prognostic factor in patients with NSCLC.

    Original languageEnglish
    Pages (from-to)3699-3704
    Number of pages6
    JournalAnticancer Research
    Volume30
    Issue number9
    StatePublished - 1 Sep 2010

    Keywords

    • Lung cancer
    • Pirh2
    • Prognosis
    • p27
    • p53

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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