@article{9f393563c1c0457a900f4a9dc5a92c51,
title = "Packaging of DNA origami in viral capsids: towards synthetic viruses",
abstract = "We report a new type of nanoparticle, consisting of a nucleic acid core (>7500 nt) folded into a 35 nm DNA origami sphere, encapsulated by a capsid composed of all three SV40 virus capsid proteins. Compared to the prototype reported previously, whose capsid consists of VP1 only, the new nanoparticle closely adopts the unique intracellular pathway of the native SV40, suggesting that the proteins of the synthetic capsid retain their native viral functionality. Some of the challenges in the design of such near-future composite drugs destined for gene delivery are discussed.",
author = "Stanislav Kler and Ran Zalk and Alexander Upcher and Idit Kopatz",
note = "Funding Information: The authors thank the teams of of the Protein Expression and the Bio-imaging Facilities of the Hebrew University of Jerusalem, in particular Yael Keren, Dr. Tsafi Danieli and Dr. Naomi Melamed-Book. The authors thank Dr. Jean-Philippe Sobczak and Dr. Tamara Aigner of tilibit nanosystems GmbH for their support. The authors would like to express their special appreciation for Prof. Ariella Oppenheim and the late prof. Amos Oppenheim for inspiring the idea of synthetic viruses. Publisher Copyright: {\textcopyright} 2022 The Royal Society of Chemistry.",
year = "2022",
month = jul,
day = "21",
doi = "10.1039/d2nr01316a",
language = "English",
volume = "14",
pages = "11535--11542",
journal = "Nanoscale",
issn = "2040-3364",
publisher = "Royal Society of Chemistry",
number = "32",
}