Palladium catalyzed 8-aminoimidazo[1,2-: A] pyridine (AIP) directed selective β-C(sp2)-H arylation

Biswajit Mondal, Prasanjit Ghosh, Mrinalkanti Kundu, Tapas Kumar Das, Sajal Das

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Palladium catalyzed arylation of the inert β-C(sp2)-H bond of carboxylic acid derivatives is reported herein for the first time utilizing 8-aminoimidazo[1,2-a]pyridine (AIP) as an efficacious and new inbuilt 6,5-fused bicyclic removable directing group. This protocol is scalable, exhibits high levels of β-site selectivity and tolerates a broad spectrum of functional groups.

Original languageEnglish
Pages (from-to)360-364
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume19
Issue number2
DOIs
StatePublished - 14 Jan 2021
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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