Palladium mediated deallylation in fully aqueous conditions for native chemical ligation at aspartic and glutamic acid sites

Muhammad Jbara, Emad Eid, Ashraf Brik

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

An efficient native chemical ligation approach at Asp and Glu sites is reported applying a hydrazide precursor, as a peptide thioester, and allyl protection at the side chain of Asp and Glu. The allyl protection was efficiently removed, after the ligation step, using the water-soluble palladium complex [Pd(allyl)Cl]2 and glutathione within a few minutes under fully aqueous conditions.

Original languageEnglish
Pages (from-to)4061-4064
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume16
Issue number22
DOIs
StatePublished - 1 Jan 2018
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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