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Pancreatic cancers require autophagy for tumor growth
Shenghong Yang
, Xiaoxu Wang
, Gianmarco Contino
, Marc Liesa
, Ergun Sahin
, Haoqiang Ying
, Alexandra Bause
, Yinghua Li
, Jayne M. Stomme
, Giacomo Dell'Antonio
, Josef Mautner
, Giovanni Tonon
, Marcia Haigis
, Orian S. Shirihai
, Claudio Doglioni
, Nabeel Bardeesy
, Alec C. Kimmelman
Research output
:
Contribution to journal
›
Article
›
peer-review
1282
Scopus citations
Overview
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Keyphrases
Tumor Growth
100%
Autophagy
100%
Pancreatic Cancer
100%
Chloroquine
18%
In Cancer
9%
Macromolecules
9%
Basal Conditions
9%
Malignancy
9%
Cancer Patients
9%
DNA Damage
9%
Cell Organelles
9%
Potent Inhibitor
9%
Pharmacological Inhibitors
9%
Primary Cells
9%
Reactive Oxygen Species
9%
Human Patients
9%
Primary Tumor
9%
Growth Suppression
9%
Prolonged Survival
9%
Tumor Subtype
9%
Tumor Regression
9%
Pancreatic Cancer Cells
9%
Genetically Engineered Mouse Models
9%
Metabolic Defects
9%
Mitochondrial Oxidative Phosphorylation
9%
Clinical Utility
9%
Survival Mechanism
9%
Synergize
9%
Targeted Agents
9%
Chemotherapy Agents
9%
Xenograft Mouse Model
9%
Catabolic Pathway
9%
Cancer Genetics
9%
Macroautophagy
9%
Cancer Xenograft
9%
Autophagy Inhibition
9%
Medicine and Dentistry
Tumor Progression
100%
Autophagy
100%
Pancreas Cancer
100%
Malignant Neoplasm
16%
Chloroquine
16%
In Vitro
8%
Cancer Cell
8%
Neoplasm
8%
Upregulation
8%
Cancer
8%
Tumor Xenograft
8%
Cell Line
8%
DNA Damage
8%
Primary Tumor
8%
Reactive Oxygen Species
8%
Oxidative Phosphorylation
8%
Growth Inhibition
8%
Tumor Regression
8%
Macroautophagy
8%
Pharmacology, Toxicology and Pharmaceutical Science
Tumor Growth
100%
Pancreas Cancer
100%
Malignant Neoplasm
25%
Chloroquine
25%
Neoplasm
12%
Mouse Model
12%
Chemotherapy
12%
Reactive Oxygen Metabolite
12%
Primary Tumor
12%
Tumor Regression
12%
Biochemistry, Genetics and Molecular Biology
Autophagy
100%
Tumor Progression
100%
Genetics
25%
Upregulation
8%
Cancer Cell
8%
Mouse Model
8%
DNA Damage
8%
Growth Inhibition
8%
Oxidative Phosphorylation
8%
Macromolecule
8%
Macroautophagy
8%