Paper radiochromatography for evaluation of radiochemical purity and stability of [186gRe]Re-HEDP in biological samples after human administration

S. Ridone, M. L. Bonardi, F. Groppi, A. Martinotti, Z. B. Alfassi

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

[186gRe]Re-HEDP is a radiopharmaceutical used for pain palliation in bone metastases from various primary tumors. The negatron emitter with 〈Eβ〉 = 357 keV 186gRe is suitable to irradiate cancer and inflammatory cells, but it needs labeling bis-phosphonates as vectors to reach target tissue. Paper radiochromatography was used to evaluate the radiochemical purity of [186gRe]Re-HEDP in radiopharmaceutical solution as well as in biological samples (serum and urine) from treated patients, in order to follow bone-targeting and excretion. Following the activity concentration in each sample vs. time it is effective to elaborate a bio-kinetic model of the radiopharmaceutical and to optimize administration protocols.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume277
Issue number1
DOIs
StatePublished - 1 Jul 2008

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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