Para-aortic and pelvic radiotherapy, an effective and safe treatment in advanced-stage uterine cancer

Alex Rabinovich, Laurence Bernard, Tamim M. Niazi, Agnihotram V. Ramanakumar, Walter H. Gotlieb, Susie Lau, Boris Bahoric

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Aim: The present, was a feasibility study of extended-field (EF) external-beam radiotherapy (EBRT) and vaginal brachytherapy (VBT) given sequentially following complete staging and adjuvant chemotherapy for patients with advanced-stage endometrial carcinoma (EC). Patients and Methods: A cohort study was carried out in 38 patients with stage IIIC and IVB EC treated by surgery, six cycles of paclitaxel-carboplatin chemotherapy followed by EF EBRT and VBT. Results: A total of 60% of the patients had non-endometrioid histology, 45% had both pelvic and para-aortic lymph node metastases. Two patients experienced recurrence in the previously irradiated field. Five-year overall and progression-free survival were 77% and 72.5%, respectively. Grade 1 diarrhea and grade 1 cystitis were the most common acute and delayed side-effects. Conclusion: EF EBRT and VBT following complete staging and adjuvant chemotherapy is a safe and effective treatment for patients with advanced-stage EC. Compared to historical data, our study suggests an improved progression-free and overall survival with acceptable acute and delayed side-effects.

Original languageEnglish
Pages (from-to)2893-2900
Number of pages8
JournalAnticancer Research
Volume35
Issue number5
StatePublished - 1 May 2015
Externally publishedYes

Keywords

  • Advanced-stage endometrial cancer
  • Extended-field external-beam radiotherapy
  • Intensity-modulated radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Para-aortic and pelvic radiotherapy, an effective and safe treatment in advanced-stage uterine cancer'. Together they form a unique fingerprint.

Cite this