Abstract
Aim: The present, was a feasibility study of extended-field (EF) external-beam radiotherapy (EBRT) and vaginal brachytherapy (VBT) given sequentially following complete staging and adjuvant chemotherapy for patients with advanced-stage endometrial carcinoma (EC). Patients and Methods: A cohort study was carried out in 38 patients with stage IIIC and IVB EC treated by surgery, six cycles of paclitaxel-carboplatin chemotherapy followed by EF EBRT and VBT. Results: A total of 60% of the patients had non-endometrioid histology, 45% had both pelvic and para-aortic lymph node metastases. Two patients experienced recurrence in the previously irradiated field. Five-year overall and progression-free survival were 77% and 72.5%, respectively. Grade 1 diarrhea and grade 1 cystitis were the most common acute and delayed side-effects. Conclusion: EF EBRT and VBT following complete staging and adjuvant chemotherapy is a safe and effective treatment for patients with advanced-stage EC. Compared to historical data, our study suggests an improved progression-free and overall survival with acceptable acute and delayed side-effects.
Original language | English |
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Pages (from-to) | 2893-2900 |
Number of pages | 8 |
Journal | Anticancer Research |
Volume | 35 |
Issue number | 5 |
State | Published - 1 May 2015 |
Externally published | Yes |
Keywords
- Advanced-stage endometrial cancer
- Extended-field external-beam radiotherapy
- Intensity-modulated radiotherapy
ASJC Scopus subject areas
- Oncology
- Cancer Research