Paraneoplastic systemic lupus erythematosus associated with dysgerminoma: a case report and literature review

Ran Ben David, Mahmoud Abu-Shakra, Mihai Meirovitz, Tsafnat Test, Nikita Medvedev, Iftach Sagy

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    Rheumatic paraneoplastic syndromes are rare and generally occur no longer than two years before diagnosis of the associated malignancy. Therefore, it can be an essential clue to occult malignancy. A healthy 18-year-old female with no underlying diseases was referred to the rheumatology clinic due to morning stiffness in her hands and a new rash on her fingers. Her labs showed a positive ANA, anti-double strand DNA antibody, anti-RNP, and anti-ribosomal P. Nine months after the diagnosis with SLE, the patient presented with elevated levels of lactate dehydrogenase. A total-body computed tomography scan revealed a solid mass in the pelvis. The pathological findings corresponded to a dysgerminoma tumor. Following surgical tumor removal and chemotherapy, the patient went into remission with both SLE and her oncology conditions, with no relapse of her lupus symptoms in a one-year follow-up. This case underscores the importance of considering malignancy in unexplained lupus symptoms, a crucial point for all physicians to be aware of. We identified 13 cases of paraneoplastic SLE in a literature review. In most cases, SLE is resolved after the tumor has been treated.

    Original languageEnglish
    JournalInternal and Emergency Medicine
    DOIs
    StateAccepted/In press - 1 Jan 2024

    Keywords

    • Dysgerminoma
    • Paraneoplastic
    • Systemic lupus erythematosus

    ASJC Scopus subject areas

    • Internal Medicine
    • Emergency Medicine

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