TY - JOUR
T1 - Paraneoplastic systemic lupus erythematosus associated with dysgerminoma
T2 - a case report and literature review
AU - Ben David, Ran
AU - Abu-Shakra, Mahmoud
AU - Meirovitz, Mihai
AU - Test, Tsafnat
AU - Medvedev, Nikita
AU - Sagy, Iftach
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI) 2024.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Rheumatic paraneoplastic syndromes are rare and generally occur no longer than two years before diagnosis of the associated malignancy. Therefore, it can be an essential clue to occult malignancy. A healthy 18-year-old female with no underlying diseases was referred to the rheumatology clinic due to morning stiffness in her hands and a new rash on her fingers. Her labs showed a positive ANA, anti-double strand DNA antibody, anti-RNP, and anti-ribosomal P. Nine months after the diagnosis with SLE, the patient presented with elevated levels of lactate dehydrogenase. A total-body computed tomography scan revealed a solid mass in the pelvis. The pathological findings corresponded to a dysgerminoma tumor. Following surgical tumor removal and chemotherapy, the patient went into remission with both SLE and her oncology conditions, with no relapse of her lupus symptoms in a one-year follow-up. This case underscores the importance of considering malignancy in unexplained lupus symptoms, a crucial point for all physicians to be aware of. We identified 13 cases of paraneoplastic SLE in a literature review. In most cases, SLE is resolved after the tumor has been treated.
AB - Rheumatic paraneoplastic syndromes are rare and generally occur no longer than two years before diagnosis of the associated malignancy. Therefore, it can be an essential clue to occult malignancy. A healthy 18-year-old female with no underlying diseases was referred to the rheumatology clinic due to morning stiffness in her hands and a new rash on her fingers. Her labs showed a positive ANA, anti-double strand DNA antibody, anti-RNP, and anti-ribosomal P. Nine months after the diagnosis with SLE, the patient presented with elevated levels of lactate dehydrogenase. A total-body computed tomography scan revealed a solid mass in the pelvis. The pathological findings corresponded to a dysgerminoma tumor. Following surgical tumor removal and chemotherapy, the patient went into remission with both SLE and her oncology conditions, with no relapse of her lupus symptoms in a one-year follow-up. This case underscores the importance of considering malignancy in unexplained lupus symptoms, a crucial point for all physicians to be aware of. We identified 13 cases of paraneoplastic SLE in a literature review. In most cases, SLE is resolved after the tumor has been treated.
KW - Dysgerminoma
KW - Paraneoplastic
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=85205758509&partnerID=8YFLogxK
U2 - 10.1007/s11739-024-03790-6
DO - 10.1007/s11739-024-03790-6
M3 - Review article
C2 - 39377884
AN - SCOPUS:85205758509
SN - 1828-0447
JO - Internal and Emergency Medicine
JF - Internal and Emergency Medicine
ER -