Parasitic Infection and Autoimmunity

Mahmoud Abu-Shakra, Eduard Ling, Yehuda Shoenfeld

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Parasitic infections are accompanied by the activation of autoimmune mechanisms. The latter include molecular mimicry between parasitic polypeptides and host antigens, the alteration of host antigens, the polyclonal activation of B cells, and the manipulation of the idiotypic networks. Protozoan diseases, such as malaria, leishmaniasis, schistosomiasis and onchocerciasis are associated with the generation of a wide spectrum of autoantibodies and are associated with autoimmune haemolytic anaemia, nephritis, autoimmune hepatitis and other clinical and laboratory autoimmune phenomena. Infestation with multicellular parasites, such as helminthes, can also lead to an immunomodulatory effect mediated by regulatory T cells and might suppress autoimmunity.

Original languageEnglish
Title of host publicationInfection and Autoimmunity
PublisherElsevier Inc.
Pages621-641
Number of pages21
ISBN (Print)9780444632692
DOIs
StatePublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Autoantibodies
  • Autoimmunity
  • Molecular mimicry
  • Parasites
  • Tregs

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology

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