Parathyroid development and the role of tubulin chaperone E

Ruti Parvari, George A. Diaz, Eli Hershkovitz

    Research output: Contribution to journalShort surveypeer-review

    27 Scopus citations

    Abstract

    The development of the parathyroid glands involves complex embryonic processes of cell-specific differentiation and migration of the glands from their sites of origin in the pharynx and pharyngeal pouches to their final positions along the ventral midline of the pharyngeal and upper thoracic region. The recognition of several distinct genetic forms of isolated and syndromic hypoparathyroidism led us to review the recent findings on the molecular mechanisms of the development of the parathyroid glands. Although far from being understood, a special emphasis was given to the possible role of tubulin chaperone E (TBCE), which was implicated in the pathogenesis of the hypopathyroidism, retardation and dysmorphism (HRD) syndrome. The novel finding that TBCE plays a critical role in the formation of the parathyroid opens a novel domain of research, not anticipated previously, into the complex process of parathyroid development.

    Original languageEnglish
    Pages (from-to)12-21
    Number of pages10
    JournalHormone Research
    Volume67
    Issue number1
    DOIs
    StatePublished - 1 Feb 2007

    Keywords

    • HRD syndrome
    • Hypoparathyroidism
    • Parathyroid glands development
    • Tubulin chaperone E

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

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