Parathyroid hormone, calcitonin, and vitamin D metabolites during normal fracture healing in humans. A preliminary report

Y. Meller, R. Shainkin-Kestenbaum, S. Shany

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The metabolism of calcium is regulated by hormones: parathyroid hormone (PTH), calcitonin (CT), and vitamin D metabolites. To study the physiologic role of these hormones during the process of fracture healing in humans, the blood levels of PTH, CT, 25-(OH)-D3, 24,25-(OH)2-D3, and calcium were determined in 13 young patients with fractures of long bones. The parameters were measured first on admission and again after six to eight weeks. A group of healthy volunteers of similar age and sex served as control subjects. Plasma calcium level on the day of fracture was significantly reduced, 8.50 ± 0.23 mg% (p < 0.001). Serum CT level on the day of fracture was significantly increased, 0.18 ± 0.02 ng/ml (p < 0.05), and it continued to increase during the healing period, up to 0.23 ± 0.02 ng/ml (p < 0.001) after six to eight weeks. A significant rise was noted in plasma level of 24,25-(OH)2-D3, from 2.02 ± 0.42 ng/ml on the day of fracture to 2.84 ± 0.41 ng/ml six weeks later (p < 0.05). No significant changes were found in serum PTH and plasma 25-(OH)-D3 levels on the day of fracture or during the healing process. The results suggest a possible physiologic active role for CT and 24,25-(OH)2-D3 in fracture healing in humans.

Original languageEnglish
Pages (from-to)238-245
Number of pages8
JournalClinical Orthopaedics and Related Research
VolumeNO. 183
StatePublished - 1 Jan 1984
Externally publishedYes

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