TY - JOUR
T1 - Parathyroid hormone, calcitonin, and vitamin D metabolites during normal fracture healing in humans. A preliminary report
AU - Meller, Y.
AU - Shainkin-Kestenbaum, R.
AU - Shany, S.
PY - 1984/1/1
Y1 - 1984/1/1
N2 - The metabolism of calcium is regulated by hormones: parathyroid hormone (PTH), calcitonin (CT), and vitamin D metabolites. To study the physiologic role of these hormones during the process of fracture healing in humans, the blood levels of PTH, CT, 25-(OH)-D3, 24,25-(OH)2-D3, and calcium were determined in 13 young patients with fractures of long bones. The parameters were measured first on admission and again after six to eight weeks. A group of healthy volunteers of similar age and sex served as control subjects. Plasma calcium level on the day of fracture was significantly reduced, 8.50 ± 0.23 mg% (p < 0.001). Serum CT level on the day of fracture was significantly increased, 0.18 ± 0.02 ng/ml (p < 0.05), and it continued to increase during the healing period, up to 0.23 ± 0.02 ng/ml (p < 0.001) after six to eight weeks. A significant rise was noted in plasma level of 24,25-(OH)2-D3, from 2.02 ± 0.42 ng/ml on the day of fracture to 2.84 ± 0.41 ng/ml six weeks later (p < 0.05). No significant changes were found in serum PTH and plasma 25-(OH)-D3 levels on the day of fracture or during the healing process. The results suggest a possible physiologic active role for CT and 24,25-(OH)2-D3 in fracture healing in humans.
AB - The metabolism of calcium is regulated by hormones: parathyroid hormone (PTH), calcitonin (CT), and vitamin D metabolites. To study the physiologic role of these hormones during the process of fracture healing in humans, the blood levels of PTH, CT, 25-(OH)-D3, 24,25-(OH)2-D3, and calcium were determined in 13 young patients with fractures of long bones. The parameters were measured first on admission and again after six to eight weeks. A group of healthy volunteers of similar age and sex served as control subjects. Plasma calcium level on the day of fracture was significantly reduced, 8.50 ± 0.23 mg% (p < 0.001). Serum CT level on the day of fracture was significantly increased, 0.18 ± 0.02 ng/ml (p < 0.05), and it continued to increase during the healing period, up to 0.23 ± 0.02 ng/ml (p < 0.001) after six to eight weeks. A significant rise was noted in plasma level of 24,25-(OH)2-D3, from 2.02 ± 0.42 ng/ml on the day of fracture to 2.84 ± 0.41 ng/ml six weeks later (p < 0.05). No significant changes were found in serum PTH and plasma 25-(OH)-D3 levels on the day of fracture or during the healing process. The results suggest a possible physiologic active role for CT and 24,25-(OH)2-D3 in fracture healing in humans.
UR - http://www.scopus.com/inward/record.url?scp=0021330616&partnerID=8YFLogxK
M3 - Article
C2 - 6697591
AN - SCOPUS:0021330616
SN - 0009-921X
VL - NO. 183
SP - 238
EP - 245
JO - Clinical Orthopaedics and Related Research
JF - Clinical Orthopaedics and Related Research
ER -