PARK16 locus: Differential effects of the non-coding rs823114 on Parkinson's disease risk, RNA expression, and DNA methylation

Orly Goldstein; Mali Gana-Weisz; Fergal Casey; Hila Meltzer-Fridrich; Or Yaacov; Yedael Y. Waldman; Dongdong Lin; Yael Mordechai; Jing Zhu; Patrick F. Cullen; Nurit Omer; Tamara Shiner; Avner Thaler; Anat Bar-Shira; Anat Mirelman; Sally John; Nir Giladi; Avi Orr-Urtreger

doi:10.1016/j.jgg.2020.10.010

PARK16 locus: Differential effects of the non-coding rs823114 on Parkinson's disease risk, RNA expression, and DNA methylation

Orly Goldstein
, Mali Gana-Weisz
, Fergal Casey
, Hila Meltzer-Fridrich
, Or Yaacov
, Yedael Y. Waldman
, Dongdong Lin
, Yael Mordechai
, Jing Zhu
, Patrick F. Cullen
, Nurit Omer
, Tamara Shiner
, Avner Thaler
, Anat Bar-Shira
, Anat Mirelman
, Sally John
, Nir Giladi
, Avi Orr-Urtreger

Research output: Contribution to journal › Letter › peer-review

5 Scopus citations

Original language	English
Pages (from-to)	341-345
Number of pages	5
Journal	Journal of Genetics and Genomics
Volume	48
Issue number	4
DOIs	https://doi.org/10.1016/j.jgg.2020.10.010
State	Published - 20 Apr 2021
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics

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10.1016/j.jgg.2020.10.010

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Goldstein, O., Gana-Weisz, M., Casey, F., Meltzer-Fridrich, H., Yaacov, O., Waldman, Y. Y., Lin, D., Mordechai, Y., Zhu, J., Cullen, P. F., Omer, N., Shiner, T., Thaler, A., Bar-Shira, A., Mirelman, A., John, S., Giladi, N., & Orr-Urtreger, A. (2021). PARK16 locus: Differential effects of the non-coding rs823114 on Parkinson's disease risk, RNA expression, and DNA methylation. Journal of Genetics and Genomics, 48(4), 341-345. https://doi.org/10.1016/j.jgg.2020.10.010

@article{6087379885684636ad3ecea256159323,

title = "PARK16 locus: Differential effects of the non-coding rs823114 on Parkinson's disease risk, RNA expression, and DNA methylation",

author = "Orly Goldstein and Mali Gana-Weisz and Fergal Casey and Hila Meltzer-Fridrich and Or Yaacov and Waldman, \{Yedael Y.\} and Dongdong Lin and Yael Mordechai and Jing Zhu and Cullen, \{Patrick F.\} and Nurit Omer and Tamara Shiner and Avner Thaler and Anat Bar-Shira and Anat Mirelman and Sally John and Nir Giladi and Avi Orr-Urtreger",

note = "Funding Information: This work was supported by Chaya Charitable Fund and Alrov Fund. We would like to thank Ravi Challa, Helen McLaughlin, and Thomas M. Carlile from Biogen for contributions to the RNAseq data generation workflow in the second cohort. We would like to thank the Genome Aggregation Database (gnomAD) and the groups that provided exome and genome variant data to this resource. A full list of contributing groups can be found at https://gnomad.broadinstitute.org/about . The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health and by NCI , NHGRI , NHLBI , NIDA , NIMH , and NINDS . The data used for the analyses described in this manuscript were obtained from the GTEx Portal on September 26, 2019. Funding Information: This work was supported by Chaya Charitable Fund and Alrov Fund. We would like to thank Ravi Challa, Helen McLaughlin, and Thomas M. Carlile from Biogen for contributions to the RNAseq data generation workflow in the second cohort. We would like to thank the Genome Aggregation Database (gnomAD) and the groups that provided exome and genome variant data to this resource. A full list of contributing groups can be found at https://gnomad.broadinstitute.org/about. The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. The data used for the analyses described in this manuscript were obtained from the GTEx Portal on September 26, 2019.",

year = "2021",

month = apr,

day = "20",

doi = "10.1016/j.jgg.2020.10.010",

language = "English",

volume = "48",

pages = "341--345",

journal = "Journal of Genetics and Genomics",

issn = "1673-8527",

publisher = "Institute of Genetics and Developmental Biology",

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}

Goldstein, O, Gana-Weisz, M, Casey, F, Meltzer-Fridrich, H, Yaacov, O, Waldman, YY, Lin, D, Mordechai, Y, Zhu, J, Cullen, PF, Omer, N, Shiner, T, Thaler, A, Bar-Shira, A, Mirelman, A, John, S, Giladi, N & Orr-Urtreger, A 2021, 'PARK16 locus: Differential effects of the non-coding rs823114 on Parkinson's disease risk, RNA expression, and DNA methylation', Journal of Genetics and Genomics, vol. 48, no. 4, pp. 341-345. https://doi.org/10.1016/j.jgg.2020.10.010

TY - JOUR

T1 - PARK16 locus

T2 - Differential effects of the non-coding rs823114 on Parkinson's disease risk, RNA expression, and DNA methylation

AU - Goldstein, Orly

AU - Gana-Weisz, Mali

AU - Casey, Fergal

AU - Meltzer-Fridrich, Hila

AU - Yaacov, Or

AU - Waldman, Yedael Y.

AU - Lin, Dongdong

AU - Mordechai, Yael

AU - Zhu, Jing

AU - Cullen, Patrick F.

AU - Omer, Nurit

AU - Shiner, Tamara

AU - Thaler, Avner

AU - Bar-Shira, Anat

AU - Mirelman, Anat

AU - John, Sally

AU - Giladi, Nir

AU - Orr-Urtreger, Avi

N1 - Funding Information: This work was supported by Chaya Charitable Fund and Alrov Fund. We would like to thank Ravi Challa, Helen McLaughlin, and Thomas M. Carlile from Biogen for contributions to the RNAseq data generation workflow in the second cohort. We would like to thank the Genome Aggregation Database (gnomAD) and the groups that provided exome and genome variant data to this resource. A full list of contributing groups can be found at https://gnomad.broadinstitute.org/about . The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health and by NCI , NHGRI , NHLBI , NIDA , NIMH , and NINDS . The data used for the analyses described in this manuscript were obtained from the GTEx Portal on September 26, 2019. Funding Information: This work was supported by Chaya Charitable Fund and Alrov Fund. We would like to thank Ravi Challa, Helen McLaughlin, and Thomas M. Carlile from Biogen for contributions to the RNAseq data generation workflow in the second cohort. We would like to thank the Genome Aggregation Database (gnomAD) and the groups that provided exome and genome variant data to this resource. A full list of contributing groups can be found at https://gnomad.broadinstitute.org/about. The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. The data used for the analyses described in this manuscript were obtained from the GTEx Portal on September 26, 2019.

PY - 2021/4/20

Y1 - 2021/4/20

UR - https://www.scopus.com/pages/publications/85103340226

U2 - 10.1016/j.jgg.2020.10.010

DO - 10.1016/j.jgg.2020.10.010

M3 - Letter

C2 - 33736926

AN - SCOPUS:85103340226

SN - 1673-8527

VL - 48

SP - 341

EP - 345

JO - Journal of Genetics and Genomics

JF - Journal of Genetics and Genomics

IS - 4

ER -

PARK16 locus: Differential effects of the non-coding rs823114 on Parkinson's disease risk, RNA expression, and DNA methylation

ASJC Scopus subject areas

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