Partial inhibition by lithium of the epinephrine-stimulated rise in plasma cyclic GMP in humans

R. H. Belmaker, M. Kon, R. P. Ebstein, H. Dasberg

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Lithium-treated and drug-free individuals were each given 0.5 mg epinephrine subcutaneously and blood samples withdrawn for measurement of plasma cyclic AMP and cyclic GMP. The rise in plasma cyclic GMP in response to epinephrine was found to be partially inhibited by lithium treatment, and previous reports of lithium inhibition of the plasma cyclic AMP rise were replicated. Effects of lithium on cyclic AMP and cyclic GMP may relate to lithium's biphasic efficacy in depression and mania.

Original languageEnglish
Pages (from-to)3-8
Number of pages6
JournalBiological Psychiatry
Volume15
Issue number1
StatePublished - 1 Jan 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biological Psychiatry

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