Pathogenesis of fibromyalgia - A review

Jacob Ablin, Lily Neumann, Dan Buskila

Research output: Contribution to journalShort surveypeer-review

105 Scopus citations


Fibromyalgia, a syndrome characterized by widespread pain and diffuse tenderness, is considered a multifactorial disorder. Central nervous system sensitization is a major pathophysiological aspect of fibromyalgia, while various external stimuli such as infection, trauma and stress may contribute to development of the syndrome. In addition, current evidence points towards the existence of a genetic basis for fibromyalgia and information has been accumulated regarding the role of a number of candidate genes in fibromyalgia pathogenesis. In the present review, we have summarized the clinical manifestations of fibromyalgia, as well as the necessary laboratory workup; subsequently we have attempted to cover various aspects of pathogenesis with special emphasis on the genetic aspects currently uncovered.

Original languageEnglish
Pages (from-to)273-279
Number of pages7
JournalJoint Bone Spine
Issue number3
StatePublished - 1 May 2008


  • Central sensitization
  • Fibromyalgia
  • Genetics
  • Pathogenesis


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