Pathogenesis of fibromyalgia - A review

Jacob Ablin, Lily Neumann, Dan Buskila

    Research output: Contribution to journalShort surveypeer-review

    111 Scopus citations


    Fibromyalgia, a syndrome characterized by widespread pain and diffuse tenderness, is considered a multifactorial disorder. Central nervous system sensitization is a major pathophysiological aspect of fibromyalgia, while various external stimuli such as infection, trauma and stress may contribute to development of the syndrome. In addition, current evidence points towards the existence of a genetic basis for fibromyalgia and information has been accumulated regarding the role of a number of candidate genes in fibromyalgia pathogenesis. In the present review, we have summarized the clinical manifestations of fibromyalgia, as well as the necessary laboratory workup; subsequently we have attempted to cover various aspects of pathogenesis with special emphasis on the genetic aspects currently uncovered.

    Original languageEnglish
    Pages (from-to)273-279
    Number of pages7
    JournalJoint Bone Spine
    Issue number3
    StatePublished - 1 May 2008


    • Central sensitization
    • Fibromyalgia
    • Genetics
    • Pathogenesis

    ASJC Scopus subject areas

    • Rheumatology


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