Pathogenesis of the antiphospholipid syndrome. The infectious agents theory

Y. Shoenfeld, M. Blank, Y. Sherer

Research output: Contribution to journalReview articlepeer-review


The antiphospholipid syndrome (APS) is characterized by the presence of pathogenic autoantibodies against β2-glycoprotein-I (β2GPI). Studies of experimental APS models emphasized that molecular mimicry between β2GPI related synthetic peptides and structures within bacteria, viruses, tetanus toxoid, and cytomegalovirus as a cause for experimental APS. In this review we discuss the association of antiphospholipid antibodies with infectious agents, molecular mimicry as a proposed cause for development of APS, and the contribution of database to this topic.

Original languageEnglish
Pages (from-to)142-145
Number of pages4
JournalProgressi in Reumatologia
Issue number2
StatePublished - 8 Nov 2004
Externally publishedYes


  • Antiphospholipid syndrome
  • Infection
  • Thrombosis

ASJC Scopus subject areas

  • Rheumatology


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