Pathogenesis of the antiphospholipid syndrome. The infectious agents theory

Y. Shoenfeld; M. Blank; Y. Sherer

Pathogenesis of the antiphospholipid syndrome. The infectious agents theory

Y. Shoenfeld, M. Blank, Y. Sherer

Research output: Contribution to journal › Review article › peer-review

Abstract

The antiphospholipid syndrome (APS) is characterized by the presence of pathogenic autoantibodies against β₂-glycoprotein-I (β₂GPI). Studies of experimental APS models emphasized that molecular mimicry between β₂GPI related synthetic peptides and structures within bacteria, viruses, tetanus toxoid, and cytomegalovirus as a cause for experimental APS. In this review we discuss the association of antiphospholipid antibodies with infectious agents, molecular mimicry as a proposed cause for development of APS, and the contribution of database to this topic.

Original language	English
Pages (from-to)	142-145
Number of pages	4
Journal	Progressi in Reumatologia
Volume	5
Issue number	2
State	Published - 8 Nov 2004
Externally published	Yes

Keywords

Antiphospholipid syndrome
Infection
Thrombosis

Cite this

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AB - The antiphospholipid syndrome (APS) is characterized by the presence of pathogenic autoantibodies against β2-glycoprotein-I (β2GPI). Studies of experimental APS models emphasized that molecular mimicry between β2GPI related synthetic peptides and structures within bacteria, viruses, tetanus toxoid, and cytomegalovirus as a cause for experimental APS. In this review we discuss the association of antiphospholipid antibodies with infectious agents, molecular mimicry as a proposed cause for development of APS, and the contribution of database to this topic.

KW - Antiphospholipid syndrome

KW - Infection

KW - Thrombosis

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JO - Progressi in Reumatologia

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SN - 1129-8758

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ER -

Pathogenesis of the antiphospholipid syndrome. The infectious agents theory

Abstract

Keywords

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