Pathogenic role and clinical relevance of antineutrophil cytoplasmic antibodies in vasculitides

Ora Shovman, Boris Gilburd, Gisele Zandman-Goddard, Yaniv Sherer, Yehuda Shoenfeld

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Within the last year, a growing body of evidence for a distinct role of antineutrophil cytoplasmic antibodies (ANCA) in the pathogenesis of ANCA-associated vasculitides (AAV) has developed. An experimental model of myeloperoxidase (MPO)-ANCA-associated vasculitis provided direct and convincing in vivo evidence that MPO-ANCA are primary pathogenic factors in small-vessel vasculitis by augmenting of leukocyte-vessel wall interaction and leukocyte-mediated vascular injury. Determination of bacterial lipopolysaccharide (LPS) effects on disease severity in a mouse model of anti-MPO-induced glomerulonephritis showed that ANCA and other proinflammatory stimuli of infectious origin acted in synergism in the development of destructive inflammation.

Original languageEnglish
Pages (from-to)292-298
Number of pages7
JournalCurrent Rheumatology Reports
Issue number4
StatePublished - 1 Aug 2006

ASJC Scopus subject areas

  • Rheumatology


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