Pathogenic significance and diagnostic value of lupus autoantibodies

Y. Tomer, D. Buskila, Y. Shoenfeld

    Research output: Contribution to journalReview articlepeer-review

    26 Scopus citations

    Abstract

    Systemic lupus erythematosus (SLE) is characterized by a panoply of autoanti-bodies (more than 50). Some of them are more prevalent (anti-ds DNA > 80%) while others are less frequently detected, but highly specific for SLE (anti-Sm, 20%). In this review we will discuss the clinical significance of anti-RNP, anti-Ro, anti-La and anti-phospholipid antibodies. We will also summarize the clinical and experimental evidence for the pathogenic role attributed to each one of these antibodies.

    Original languageEnglish
    Pages (from-to)293-306
    Number of pages14
    JournalInternational Archives of Allergy and Immunology
    Volume100
    Issue number4
    DOIs
    StatePublished - 1 Jan 1993

    Keywords

    • Anti-DNA
    • Anti-cardiolipin
    • Autoantibodies
    • Autoimmunity
    • RNP
    • Rheumatoid factor
    • SLE
    • SSA
    • SSB

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

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