Pathogenic significance and diagnostic value of lupus autoantibodies

Y. Tomer; D. Buskila; Y. Shoenfeld

doi:10.1159/000236429

Pathogenic significance and diagnostic value of lupus autoantibodies

Y. Tomer, D. Buskila, Y. Shoenfeld

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is characterized by a panoply of autoanti-bodies (more than 50). Some of them are more prevalent (anti-ds DNA > 80%) while others are less frequently detected, but highly specific for SLE (anti-Sm, 20%). In this review we will discuss the clinical significance of anti-RNP, anti-Ro, anti-La and anti-phospholipid antibodies. We will also summarize the clinical and experimental evidence for the pathogenic role attributed to each one of these antibodies.

Original language	English
Pages (from-to)	293-306
Number of pages	14
Journal	International Archives of Allergy and Immunology
Volume	100
Issue number	4
DOIs	https://doi.org/10.1159/000236429
State	Published - 1 Jan 1993

Keywords

Anti-DNA
Anti-cardiolipin
Autoantibodies
Autoimmunity
RNP
Rheumatoid factor
SLE
SSA
SSB

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1159/000236429

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title = "Pathogenic significance and diagnostic value of lupus autoantibodies",

abstract = "Systemic lupus erythematosus (SLE) is characterized by a panoply of autoanti-bodies (more than 50). Some of them are more prevalent (anti-ds DNA > 80%) while others are less frequently detected, but highly specific for SLE (anti-Sm, 20%). In this review we will discuss the clinical significance of anti-RNP, anti-Ro, anti-La and anti-phospholipid antibodies. We will also summarize the clinical and experimental evidence for the pathogenic role attributed to each one of these antibodies.",

keywords = "Anti-DNA, Anti-cardiolipin, Autoantibodies, Autoimmunity, RNP, Rheumatoid factor, SLE, SSA, SSB",

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AU - Tomer, Y.

AU - Buskila, D.

AU - Shoenfeld, Y.

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N2 - Systemic lupus erythematosus (SLE) is characterized by a panoply of autoanti-bodies (more than 50). Some of them are more prevalent (anti-ds DNA > 80%) while others are less frequently detected, but highly specific for SLE (anti-Sm, 20%). In this review we will discuss the clinical significance of anti-RNP, anti-Ro, anti-La and anti-phospholipid antibodies. We will also summarize the clinical and experimental evidence for the pathogenic role attributed to each one of these antibodies.

AB - Systemic lupus erythematosus (SLE) is characterized by a panoply of autoanti-bodies (more than 50). Some of them are more prevalent (anti-ds DNA > 80%) while others are less frequently detected, but highly specific for SLE (anti-Sm, 20%). In this review we will discuss the clinical significance of anti-RNP, anti-Ro, anti-La and anti-phospholipid antibodies. We will also summarize the clinical and experimental evidence for the pathogenic role attributed to each one of these antibodies.

KW - Anti-DNA

KW - Anti-cardiolipin

KW - Autoantibodies

KW - Autoimmunity

KW - RNP

KW - Rheumatoid factor

KW - SLE

KW - SSA

KW - SSB

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JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

IS - 4

ER -

Pathogenic significance and diagnostic value of lupus autoantibodies

Abstract

Keywords

ASJC Scopus subject areas

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