Patterned DNA Metallization by Sequence-Specific Localization of a Reducing Agent

Kinneret Keren, Rotem S. Berman, Erez Braun

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


Localization of a reducing agent, glutaraldehyde, on DNA molecules directs their metallization into highly conductive wires. DNA can be marked for metallization by aldehyde derivatization while retaining its biological functionality. Patterning the aldehyde derivatization of the DNA molecules in a sequence-specific manner allows to embed the precise metallization pattern into the DNA scaffold without compromising its recognition capabilities or biological functionality. We demonstrate scaffold DNA patterning by hybridization of aldehyde-derivatized and underivatized DNA molecules and by sequence-specific protection against aldehyde derivatization. This approach opens new possibilities in wiring of complex molecular-scale electronic circuits.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalNano Letters
Issue number2
StatePublished - 1 Feb 2004
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering


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