Patterned DNA Metallization by Sequence-Specific Localization of a Reducing Agent

Kinneret Keren; Rotem S. Berman; Erez Braun

doi:10.1021/nl035124z

Patterned DNA Metallization by Sequence-Specific Localization of a Reducing Agent

Kinneret Keren, Rotem S. Berman, Erez Braun

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

Localization of a reducing agent, glutaraldehyde, on DNA molecules directs their metallization into highly conductive wires. DNA can be marked for metallization by aldehyde derivatization while retaining its biological functionality. Patterning the aldehyde derivatization of the DNA molecules in a sequence-specific manner allows to embed the precise metallization pattern into the DNA scaffold without compromising its recognition capabilities or biological functionality. We demonstrate scaffold DNA patterning by hybridization of aldehyde-derivatized and underivatized DNA molecules and by sequence-specific protection against aldehyde derivatization. This approach opens new possibilities in wiring of complex molecular-scale electronic circuits.

Original language	English
Pages (from-to)	323-326
Number of pages	4
Journal	Nano Letters
Volume	4
Issue number	2
DOIs	https://doi.org/10.1021/nl035124z
State	Published - 1 Feb 2004
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Chemistry (all)
Materials Science (all)
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl035124z

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abstract = "Localization of a reducing agent, glutaraldehyde, on DNA molecules directs their metallization into highly conductive wires. DNA can be marked for metallization by aldehyde derivatization while retaining its biological functionality. Patterning the aldehyde derivatization of the DNA molecules in a sequence-specific manner allows to embed the precise metallization pattern into the DNA scaffold without compromising its recognition capabilities or biological functionality. We demonstrate scaffold DNA patterning by hybridization of aldehyde-derivatized and underivatized DNA molecules and by sequence-specific protection against aldehyde derivatization. This approach opens new possibilities in wiring of complex molecular-scale electronic circuits.",

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AB - Localization of a reducing agent, glutaraldehyde, on DNA molecules directs their metallization into highly conductive wires. DNA can be marked for metallization by aldehyde derivatization while retaining its biological functionality. Patterning the aldehyde derivatization of the DNA molecules in a sequence-specific manner allows to embed the precise metallization pattern into the DNA scaffold without compromising its recognition capabilities or biological functionality. We demonstrate scaffold DNA patterning by hybridization of aldehyde-derivatized and underivatized DNA molecules and by sequence-specific protection against aldehyde derivatization. This approach opens new possibilities in wiring of complex molecular-scale electronic circuits.

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Patterned DNA Metallization by Sequence-Specific Localization of a Reducing Agent

Abstract

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