TY - JOUR
T1 - PCI complexes
T2 - Pretty complex interactions in diverse signaling pathways
AU - Kim, Tae Houn
AU - Hofmann, Kay
AU - Von Arnim, Albrecht G.
AU - Chamovitz, Daniel A.
N1 - Funding Information:
Our research on the interactions between the CSN and eIF3 was supported by a grant from the USA–Israel Binational Science Foundations (96-00258).
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001/12/29
Y1 - 2001/12/29
N2 - Three protein complexes (the proteasome regulatory lid, the COP9 signalosome and eukaryotic translation initiation factor 3) contain protein subunits with a well defined protein domain, the PCI domain. At least two (the COP9 signalosome and the lid) appear to share a common evolutionary origin. Recent advances in our understanding of the structure and function of the three complexes point to intriguing and unanticipated connections between the cellular functions performed by these three protein assemblies, especially between translation initiation and proteolytic protein degradation.
AB - Three protein complexes (the proteasome regulatory lid, the COP9 signalosome and eukaryotic translation initiation factor 3) contain protein subunits with a well defined protein domain, the PCI domain. At least two (the COP9 signalosome and the lid) appear to share a common evolutionary origin. Recent advances in our understanding of the structure and function of the three complexes point to intriguing and unanticipated connections between the cellular functions performed by these three protein assemblies, especially between translation initiation and proteolytic protein degradation.
UR - http://www.scopus.com/inward/record.url?scp=0035206221&partnerID=8YFLogxK
U2 - 10.1016/S1360-1385(01)02015-5
DO - 10.1016/S1360-1385(01)02015-5
M3 - Review article
AN - SCOPUS:0035206221
SN - 1360-1385
VL - 6
SP - 379
EP - 386
JO - Trends in Plant Science
JF - Trends in Plant Science
IS - 8
ER -