Pd-catalysed regioselective cross dehydrogenative coupling of quinazolinones with aromatic carboxylic acids

Deepali S. Waghmare; Priyanka M. Lagad; Umesh A. Kshirsagar; Vaishali S. Shinde

doi:10.1016/j.tetlet.2024.155214

Pd-catalysed regioselective cross dehydrogenative coupling of quinazolinones with aromatic carboxylic acids

Deepali S. Waghmare, Priyanka M. Lagad, Umesh A. Kshirsagar, Vaishali S. Shinde

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A simple protocol for a regioselective cross dehydrogenative reaction of 2-aryl-quinazolinones with different phenyl carboxylic acids was developed using a palladium catalyst facilitated by C–H activation. Simple and readily accessible aromatic carboxylic acids were utilized as a source of benzoxylate. A one-pot method proceeded with great regioselectivity and offered mono benzoxylation product with moderate to excellent yield.

Original language	English
Article number	155214
Journal	Tetrahedron Letters
Volume	147
DOIs	https://doi.org/10.1016/j.tetlet.2024.155214
State	Published - 1 Sep 2024
Externally published	Yes

Keywords

Ceric ammonium nitrate
Cross dehydrogenative coupling
C–H activation
Palladium catalysis
Quinazolinone

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2024.155214

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title = "Pd-catalysed regioselective cross dehydrogenative coupling of quinazolinones with aromatic carboxylic acids",

abstract = "A simple protocol for a regioselective cross dehydrogenative reaction of 2-aryl-quinazolinones with different phenyl carboxylic acids was developed using a palladium catalyst facilitated by C–H activation. Simple and readily accessible aromatic carboxylic acids were utilized as a source of benzoxylate. A one-pot method proceeded with great regioselectivity and offered mono benzoxylation product with moderate to excellent yield.",

keywords = "Ceric ammonium nitrate, Cross dehydrogenative coupling, C–H activation, Palladium catalysis, Quinazolinone",

author = "Waghmare, \{Deepali S.\} and Lagad, \{Priyanka M.\} and Kshirsagar, \{Umesh A.\} and Shinde, \{Vaishali S.\}",

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year = "2024",

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doi = "10.1016/j.tetlet.2024.155214",

language = "English",

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journal = "Tetrahedron Letters",

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T1 - Pd-catalysed regioselective cross dehydrogenative coupling of quinazolinones with aromatic carboxylic acids

AU - Waghmare, Deepali S.

AU - Lagad, Priyanka M.

AU - Kshirsagar, Umesh A.

AU - Shinde, Vaishali S.

PY - 2024/9/1

Y1 - 2024/9/1

N2 - A simple protocol for a regioselective cross dehydrogenative reaction of 2-aryl-quinazolinones with different phenyl carboxylic acids was developed using a palladium catalyst facilitated by C–H activation. Simple and readily accessible aromatic carboxylic acids were utilized as a source of benzoxylate. A one-pot method proceeded with great regioselectivity and offered mono benzoxylation product with moderate to excellent yield.

AB - A simple protocol for a regioselective cross dehydrogenative reaction of 2-aryl-quinazolinones with different phenyl carboxylic acids was developed using a palladium catalyst facilitated by C–H activation. Simple and readily accessible aromatic carboxylic acids were utilized as a source of benzoxylate. A one-pot method proceeded with great regioselectivity and offered mono benzoxylation product with moderate to excellent yield.

KW - Ceric ammonium nitrate

KW - Cross dehydrogenative coupling

KW - C–H activation

KW - Palladium catalysis

KW - Quinazolinone

UR - https://www.scopus.com/pages/publications/85199809437

U2 - 10.1016/j.tetlet.2024.155214

DO - 10.1016/j.tetlet.2024.155214

M3 - Article

AN - SCOPUS:85199809437

SN - 0040-4039

VL - 147

JO - Tetrahedron Letters

JF - Tetrahedron Letters

M1 - 155214

ER -

Pd-catalysed regioselective cross dehydrogenative coupling of quinazolinones with aromatic carboxylic acids

Abstract

Keywords

ASJC Scopus subject areas

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