Pd-Catalyzed Decarboxylative Ortho-Aroylation of 2-Aryl-quinazolinone Comprising Intrinsic Directing Group with α-Oxocarboxylic Acids

Deepali S. Waghmare; Shrikant D. Tambe; Umesh A. Kshirsagar

doi:10.1002/ajoc.202000487

Pd-Catalyzed Decarboxylative Ortho-Aroylation of 2-Aryl-quinazolinone Comprising Intrinsic Directing Group with α-Oxocarboxylic Acids

Deepali S. Waghmare, Shrikant D. Tambe, Umesh A. Kshirsagar

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Pd-catalyzed decarboxylative ortho-aroylation of 2-aryl-quinazolinones with α-oxocarboxylic acids for the synthesis of diaryl ketones has been developed. Biologically interested novel quinazolinones with diaryl ketone functionality has been obtained with moderate to excellent yield from easily accessible 2-aryl-quinazolinones having inherent directing group.

Original language	English
Pages (from-to)	2095-2098
Number of pages	4
Journal	Asian Journal of Organic Chemistry
Volume	9
Issue number	12
DOIs	https://doi.org/10.1002/ajoc.202000487
State	Published - 1 Dec 2020
Externally published	Yes

Keywords

C−H activation
F.C. acylation
Quinazolinone
catalysis
decarboxylative coupling

ASJC Scopus subject areas

Organic Chemistry

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10.1002/ajoc.202000487

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title = "Pd-Catalyzed Decarboxylative Ortho-Aroylation of 2-Aryl-quinazolinone Comprising Intrinsic Directing Group with α-Oxocarboxylic Acids",

abstract = "Pd-catalyzed decarboxylative ortho-aroylation of 2-aryl-quinazolinones with α-oxocarboxylic acids for the synthesis of diaryl ketones has been developed. Biologically interested novel quinazolinones with diaryl ketone functionality has been obtained with moderate to excellent yield from easily accessible 2-aryl-quinazolinones having inherent directing group.",

keywords = "C−H activation, F.C. acylation, Quinazolinone, catalysis, decarboxylative coupling",

author = "Waghmare, {Deepali S.} and Tambe, {Shrikant D.} and Kshirsagar, {Umesh A.}",

note = "Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH",

year = "2020",

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doi = "10.1002/ajoc.202000487",

language = "English",

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AU - Waghmare, Deepali S.

AU - Tambe, Shrikant D.

AU - Kshirsagar, Umesh A.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Pd-catalyzed decarboxylative ortho-aroylation of 2-aryl-quinazolinones with α-oxocarboxylic acids for the synthesis of diaryl ketones has been developed. Biologically interested novel quinazolinones with diaryl ketone functionality has been obtained with moderate to excellent yield from easily accessible 2-aryl-quinazolinones having inherent directing group.

AB - Pd-catalyzed decarboxylative ortho-aroylation of 2-aryl-quinazolinones with α-oxocarboxylic acids for the synthesis of diaryl ketones has been developed. Biologically interested novel quinazolinones with diaryl ketone functionality has been obtained with moderate to excellent yield from easily accessible 2-aryl-quinazolinones having inherent directing group.

KW - C−H activation

KW - F.C. acylation

KW - Quinazolinone

KW - catalysis

KW - decarboxylative coupling

UR - http://www.scopus.com/inward/record.url?scp=85096649351&partnerID=8YFLogxK

U2 - 10.1002/ajoc.202000487

DO - 10.1002/ajoc.202000487

M3 - Article

AN - SCOPUS:85096649351

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VL - 9

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EP - 2098

JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

IS - 12

ER -

Pd-Catalyzed Decarboxylative Ortho-Aroylation of 2-Aryl-quinazolinone Comprising Intrinsic Directing Group with α-Oxocarboxylic Acids

Abstract

Keywords

ASJC Scopus subject areas

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