Pd-catalyzed homo-coupling of benzofurans: one-pot synthesis of diverse 3,3′-bisbenzofurans

Kishan Gugulothu; Ramanna Jatoth; Ramakrishna Gudipati; Nampally Rajitha; Rambabu Dandela; K. Shiva Kumar

doi:10.1039/d3ob00658a

Pd-catalyzed homo-coupling of benzofurans: one-pot synthesis of diverse 3,3′-bisbenzofurans

Kishan Gugulothu, Ramanna Jatoth, Ramakrishna Gudipati, Nampally Rajitha, Rambabu Dandela, K. Shiva Kumar

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

An efficient and one-pot synthesis of 3,3′-bisbenzofuran derivatives has been developed. The protocol involved the use of a Pd catalyst and Cu(OAc)₂ along with molecular oxygen as the oxidant to afford bisbenzofurans via a dehydrogenative homo-coupling reaction. The reaction exhibited good functional group/heterocycle tolerance and is amenable for gram scale synthesis.

Original language	English
Pages (from-to)	5587-5591
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	21
Issue number	27
DOIs	https://doi.org/10.1039/d3ob00658a
State	Published - 19 Jun 2023
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1039/d3ob00658a

Cite this

@article{2bc6713411bc44bbb5d3c577f735f842,

title = "Pd-catalyzed homo-coupling of benzofurans: one-pot synthesis of diverse 3,3′-bisbenzofurans",

abstract = "An efficient and one-pot synthesis of 3,3′-bisbenzofuran derivatives has been developed. The protocol involved the use of a Pd catalyst and Cu(OAc)2 along with molecular oxygen as the oxidant to afford bisbenzofurans via a dehydrogenative homo-coupling reaction. The reaction exhibited good functional group/heterocycle tolerance and is amenable for gram scale synthesis.",

author = "Kishan Gugulothu and Ramanna Jatoth and Ramakrishna Gudipati and Nampally Rajitha and Rambabu Dandela and {Shiva Kumar}, K.",

note = "Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",

year = "2023",

month = jun,

day = "19",

doi = "10.1039/d3ob00658a",

language = "English",

volume = "21",

pages = "5587--5591",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "27",

}

TY - JOUR

T1 - Pd-catalyzed homo-coupling of benzofurans

T2 - one-pot synthesis of diverse 3,3′-bisbenzofurans

AU - Gugulothu, Kishan

AU - Jatoth, Ramanna

AU - Gudipati, Ramakrishna

AU - Rajitha, Nampally

AU - Dandela, Rambabu

AU - Shiva Kumar, K.

PY - 2023/6/19

Y1 - 2023/6/19

N2 - An efficient and one-pot synthesis of 3,3′-bisbenzofuran derivatives has been developed. The protocol involved the use of a Pd catalyst and Cu(OAc)2 along with molecular oxygen as the oxidant to afford bisbenzofurans via a dehydrogenative homo-coupling reaction. The reaction exhibited good functional group/heterocycle tolerance and is amenable for gram scale synthesis.

AB - An efficient and one-pot synthesis of 3,3′-bisbenzofuran derivatives has been developed. The protocol involved the use of a Pd catalyst and Cu(OAc)2 along with molecular oxygen as the oxidant to afford bisbenzofurans via a dehydrogenative homo-coupling reaction. The reaction exhibited good functional group/heterocycle tolerance and is amenable for gram scale synthesis.

UR - http://www.scopus.com/inward/record.url?scp=85164280050&partnerID=8YFLogxK

U2 - 10.1039/d3ob00658a

DO - 10.1039/d3ob00658a

M3 - Article

C2 - 37358031

AN - SCOPUS:85164280050

SN - 1477-0520

VL - 21

SP - 5587

EP - 5591

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 27

ER -

Pd-catalyzed homo-coupling of benzofurans: one-pot synthesis of diverse 3,3′-bisbenzofurans

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this