Pd/C-mediated depropargylation of propargyl ethers/amines in water

D. Rambabu; S. Bhavani; Nalivela Kumara Swamy; M. V. Basaveswara Rao; Manojit Pal

doi:10.1016/j.tetlet.2012.12.093

Pd/C-mediated depropargylation of propargyl ethers/amines in water

D. Rambabu, S. Bhavani, Nalivela Kumara Swamy, M. V. Basaveswara Rao, Manojit Pal

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Propargyl ethers and amines are effectively depropargylated to the parent alcohols or amines via a C-O/C-N bond cleavage catalyzed by 10% Pd/C in water. This simple, facile, and inexpensive methodology could be utilized for the selective removal of propargyl groups from a variety of aryl ethers and amines.

Original language	English
Pages (from-to)	1169-1173
Number of pages	5
Journal	Tetrahedron Letters
Volume	54
Issue number	9
DOIs	https://doi.org/10.1016/j.tetlet.2012.12.093
State	Published - 27 Feb 2013
Externally published	Yes

Keywords

Deprotection
Pd/C
Propargyl ether/amine
Water

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2012.12.093

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title = "Pd/C-mediated depropargylation of propargyl ethers/amines in water",

abstract = "Propargyl ethers and amines are effectively depropargylated to the parent alcohols or amines via a C-O/C-N bond cleavage catalyzed by 10% Pd/C in water. This simple, facile, and inexpensive methodology could be utilized for the selective removal of propargyl groups from a variety of aryl ethers and amines.",

keywords = "Deprotection, Pd/C, Propargyl ether/amine, Water",

author = "D. Rambabu and S. Bhavani and Swamy, {Nalivela Kumara} and {Basaveswara Rao}, {M. V.} and Manojit Pal",

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T1 - Pd/C-mediated depropargylation of propargyl ethers/amines in water

AU - Rambabu, D.

AU - Bhavani, S.

AU - Swamy, Nalivela Kumara

AU - Basaveswara Rao, M. V.

AU - Pal, Manojit

PY - 2013/2/27

Y1 - 2013/2/27

N2 - Propargyl ethers and amines are effectively depropargylated to the parent alcohols or amines via a C-O/C-N bond cleavage catalyzed by 10% Pd/C in water. This simple, facile, and inexpensive methodology could be utilized for the selective removal of propargyl groups from a variety of aryl ethers and amines.

AB - Propargyl ethers and amines are effectively depropargylated to the parent alcohols or amines via a C-O/C-N bond cleavage catalyzed by 10% Pd/C in water. This simple, facile, and inexpensive methodology could be utilized for the selective removal of propargyl groups from a variety of aryl ethers and amines.

KW - Deprotection

KW - Pd/C

KW - Propargyl ether/amine

KW - Water

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U2 - 10.1016/j.tetlet.2012.12.093

DO - 10.1016/j.tetlet.2012.12.093

M3 - Article

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JF - Tetrahedron Letters

IS - 9

ER -

Pd/C-mediated depropargylation of propargyl ethers/amines in water

Abstract

Keywords

ASJC Scopus subject areas

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