(Pd/C-mediated)coupling-iodocyclization-coupling strategy in discovery of novel PDE4 inhibitors: A new synthesis of pyrazolopyrimidines

P. Mahesh Kumar; K. Siva Kumar; Chandana L.T. Meda; G. Rajeshwar Reddy; Pradeep K. Mohakhud; K. Mukkanti; G. Rama Krishna; C. Malla Reddy; D. Rambabu; K. Shiva Kumar; K. Krishna Priya; Keerthana Sarma Chennubhotla; Rakesh Kumar Banote; Pushkar Kulkarni; Kishore V.L. Parsa; Manojit Pal

doi:10.1039/c2md00273f

(Pd/C-mediated)coupling-iodocyclization-coupling strategy in discovery of novel PDE4 inhibitors: A new synthesis of pyrazolopyrimidines

P. Mahesh Kumar, K. Siva Kumar, Chandana L.T. Meda, G. Rajeshwar Reddy, Pradeep K. Mohakhud, K. Mukkanti, G. Rama Krishna, C. Malla Reddy, D. Rambabu, K. Shiva Kumar, K. Krishna Priya, Keerthana Sarma Chennubhotla, Rakesh Kumar Banote, Pushkar Kulkarni, Kishore V.L. Parsa, Manojit Pal

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Pyranones fused with a pyrazolopyrimidine moiety were prepared via regioselective construction of pyranone ring using (Pd/C-mediated)coupling- iodocyclization followed by Sonogashira/Heck/Suzuki reactions. The pyrazolopyrimidine based reactant required was obtained via a new H ₃PO₃ mediated condensation reaction. This strategy has led to the discovery of a novel and potentially safe PDE4 inhibitor.

Original language	English
Pages (from-to)	667-672
Number of pages	6
Journal	MedChemComm
Volume	3
Issue number	6
DOIs	https://doi.org/10.1039/c2md00273f
State	Published - 1 Jan 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

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Kumar, P. M., Kumar, K. S., Meda, C. L. T., Reddy, G. R., Mohakhud, P. K., Mukkanti, K., Krishna, G. R., Reddy, C. M., Rambabu, D., Kumar, K. S., Priya, K. K., Chennubhotla, K. S., Banote, R. K., Kulkarni, P., Parsa, K. V. L., & Pal, M. (2012). (Pd/C-mediated)coupling-iodocyclization-coupling strategy in discovery of novel PDE4 inhibitors: A new synthesis of pyrazolopyrimidines. MedChemComm, 3(6), 667-672. https://doi.org/10.1039/c2md00273f

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title = "(Pd/C-mediated)coupling-iodocyclization-coupling strategy in discovery of novel PDE4 inhibitors: A new synthesis of pyrazolopyrimidines",

abstract = "Pyranones fused with a pyrazolopyrimidine moiety were prepared via regioselective construction of pyranone ring using (Pd/C-mediated)coupling- iodocyclization followed by Sonogashira/Heck/Suzuki reactions. The pyrazolopyrimidine based reactant required was obtained via a new H 3PO3 mediated condensation reaction. This strategy has led to the discovery of a novel and potentially safe PDE4 inhibitor.",

author = "Kumar, {P. Mahesh} and Kumar, {K. Siva} and Meda, {Chandana L.T.} and Reddy, {G. Rajeshwar} and Mohakhud, {Pradeep K.} and K. Mukkanti and Krishna, {G. Rama} and Reddy, {C. Malla} and D. Rambabu and Kumar, {K. Shiva} and Priya, {K. Krishna} and Chennubhotla, {Keerthana Sarma} and Banote, {Rakesh Kumar} and Pushkar Kulkarni and Parsa, {Kishore V.L.} and Manojit Pal",

year = "2012",

month = jan,

day = "1",

doi = "10.1039/c2md00273f",

language = "English",

volume = "3",

pages = "667--672",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

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Kumar, PM, Kumar, KS, Meda, CLT, Reddy, GR, Mohakhud, PK, Mukkanti, K, Krishna, GR, Reddy, CM, Rambabu, D, Kumar, KS, Priya, KK, Chennubhotla, KS, Banote, RK, Kulkarni, P, Parsa, KVL & Pal, M 2012, '(Pd/C-mediated)coupling-iodocyclization-coupling strategy in discovery of novel PDE4 inhibitors: A new synthesis of pyrazolopyrimidines', MedChemComm, vol. 3, no. 6, pp. 667-672. https://doi.org/10.1039/c2md00273f

TY - JOUR

T1 - (Pd/C-mediated)coupling-iodocyclization-coupling strategy in discovery of novel PDE4 inhibitors

T2 - A new synthesis of pyrazolopyrimidines

AU - Kumar, P. Mahesh

AU - Kumar, K. Siva

AU - Meda, Chandana L.T.

AU - Reddy, G. Rajeshwar

AU - Mohakhud, Pradeep K.

AU - Mukkanti, K.

AU - Krishna, G. Rama

AU - Reddy, C. Malla

AU - Rambabu, D.

AU - Kumar, K. Shiva

AU - Priya, K. Krishna

AU - Chennubhotla, Keerthana Sarma

AU - Banote, Rakesh Kumar

AU - Kulkarni, Pushkar

AU - Parsa, Kishore V.L.

AU - Pal, Manojit

PY - 2012/1/1

Y1 - 2012/1/1

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AB - Pyranones fused with a pyrazolopyrimidine moiety were prepared via regioselective construction of pyranone ring using (Pd/C-mediated)coupling- iodocyclization followed by Sonogashira/Heck/Suzuki reactions. The pyrazolopyrimidine based reactant required was obtained via a new H 3PO3 mediated condensation reaction. This strategy has led to the discovery of a novel and potentially safe PDE4 inhibitor.

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U2 - 10.1039/c2md00273f

DO - 10.1039/c2md00273f

M3 - Article

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JO - MedChemComm

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IS - 6

ER -

(Pd/C-mediated)coupling-iodocyclization-coupling strategy in discovery of novel PDE4 inhibitors: A new synthesis of pyrazolopyrimidines

Abstract

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