PEDOT decorated with PTIR nanoclusters on carbon fiber paper toward electrocatalytic reduction of a hypertensive drug olmesartan medoxomil

K. B. Akshaya; T. P. Vinod; M. Nidhin; Anitha Varghese; Louis George

doi:10.1149/2.0671813jes

PEDOT decorated with PTIR nanoclusters on carbon fiber paper toward electrocatalytic reduction of a hypertensive drug olmesartan medoxomil

K. B. Akshaya, T. P. Vinod, M. Nidhin, Anitha Varghese, Louis George

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

A facile electrochemical sensor was developed by electrochemical deposition of PtIr nanoparticles on poly(3,4ethylenedioxythiophene) (PEDOT) modified carbon fiber paper electrode (CFP). The modified electrodes were characterized by Field emission scanning electron microscopy (FESEM) with energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), RAMAN spectroscopy, Fourier transform infrared spectroscopy (FTIR) and electroanalytical techniques. PtIr-PEDOT modified CFP electrode was used successfully in the determination of an anti-hypertensive prodrug Olmesartan medoxomil (OM) at femtomolar (fM) level for the first time. Under optimal conditions, the prepared electrochemical sensor has shown broad linear range between 0.001 pM and 0.220 pM and superior detection limit of 3.42 fM was observed based on Differential pulse voltammetric (DPV) study. In addition, the designed electrochemical sensor was successfully demonstrated as a novel platform in the electrochemical determination of OM in human urine and pharmaceutical samples.

Original language	English
Pages (from-to)	B582-B595
Journal	Journal of the Electrochemical Society
Volume	165
Issue number	13
DOIs	https://doi.org/10.1149/2.0671813jes
State	Published - 1 Jan 2018
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Renewable Energy, Sustainability and the Environment
Condensed Matter Physics
Surfaces, Coatings and Films
Electrochemistry
Materials Chemistry

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title = "PEDOT decorated with PTIR nanoclusters on carbon fiber paper toward electrocatalytic reduction of a hypertensive drug olmesartan medoxomil",

abstract = "A facile electrochemical sensor was developed by electrochemical deposition of PtIr nanoparticles on poly(3,4ethylenedioxythiophene) (PEDOT) modified carbon fiber paper electrode (CFP). The modified electrodes were characterized by Field emission scanning electron microscopy (FESEM) with energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), RAMAN spectroscopy, Fourier transform infrared spectroscopy (FTIR) and electroanalytical techniques. PtIr-PEDOT modified CFP electrode was used successfully in the determination of an anti-hypertensive prodrug Olmesartan medoxomil (OM) at femtomolar (fM) level for the first time. Under optimal conditions, the prepared electrochemical sensor has shown broad linear range between 0.001 pM and 0.220 pM and superior detection limit of 3.42 fM was observed based on Differential pulse voltammetric (DPV) study. In addition, the designed electrochemical sensor was successfully demonstrated as a novel platform in the electrochemical determination of OM in human urine and pharmaceutical samples.",

author = "Akshaya, {K. B.} and Vinod, {T. P.} and M. Nidhin and Anitha Varghese and Louis George",

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AU - Akshaya, K. B.

AU - Vinod, T. P.

AU - Nidhin, M.

AU - Varghese, Anitha

AU - George, Louis

PY - 2018/1/1

Y1 - 2018/1/1

N2 - A facile electrochemical sensor was developed by electrochemical deposition of PtIr nanoparticles on poly(3,4ethylenedioxythiophene) (PEDOT) modified carbon fiber paper electrode (CFP). The modified electrodes were characterized by Field emission scanning electron microscopy (FESEM) with energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), RAMAN spectroscopy, Fourier transform infrared spectroscopy (FTIR) and electroanalytical techniques. PtIr-PEDOT modified CFP electrode was used successfully in the determination of an anti-hypertensive prodrug Olmesartan medoxomil (OM) at femtomolar (fM) level for the first time. Under optimal conditions, the prepared electrochemical sensor has shown broad linear range between 0.001 pM and 0.220 pM and superior detection limit of 3.42 fM was observed based on Differential pulse voltammetric (DPV) study. In addition, the designed electrochemical sensor was successfully demonstrated as a novel platform in the electrochemical determination of OM in human urine and pharmaceutical samples.

AB - A facile electrochemical sensor was developed by electrochemical deposition of PtIr nanoparticles on poly(3,4ethylenedioxythiophene) (PEDOT) modified carbon fiber paper electrode (CFP). The modified electrodes were characterized by Field emission scanning electron microscopy (FESEM) with energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), RAMAN spectroscopy, Fourier transform infrared spectroscopy (FTIR) and electroanalytical techniques. PtIr-PEDOT modified CFP electrode was used successfully in the determination of an anti-hypertensive prodrug Olmesartan medoxomil (OM) at femtomolar (fM) level for the first time. Under optimal conditions, the prepared electrochemical sensor has shown broad linear range between 0.001 pM and 0.220 pM and superior detection limit of 3.42 fM was observed based on Differential pulse voltammetric (DPV) study. In addition, the designed electrochemical sensor was successfully demonstrated as a novel platform in the electrochemical determination of OM in human urine and pharmaceutical samples.

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PEDOT decorated with PTIR nanoclusters on carbon fiber paper toward electrocatalytic reduction of a hypertensive drug olmesartan medoxomil

Abstract

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