PEG-PLA block copolymer as potential drug carrier: Preparation and characterization

Shimon Ben-Shabat; Neeraj Kumar; Abraham J. Domb

doi:10.1002/mabi.200600165

PEG-PLA block copolymer as potential drug carrier: Preparation and characterization

Shimon Ben-Shabat, Neeraj Kumar, Abraham J. Domb

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Diblock and multiblock copolymers composed of a poly(D,L-lactide) (PLA) or poly(trimethylene carbonate) (PTMC) core with a hydrophilic chain of poly(ethylene glycol) (PEG) were prepared. These copolymers, in which the core is connected to PEG through a polyfunctional molecule such as citric, mucic, or tartaric acid, may be used to form nanoparticles for drug delivery applications. Branched copolymers were prepared by direct amidation between the polyfunctional acid and methoxy PEGamine, followed by ring-opening polymerization of lactide or trimethyl carbonate to form the PLA and PTMC block copolymers. In addition, a complex multiblock copolymer of biotin-PEG- poly[lactic-co-(glycolic acid)] (PLGA) for application in an avidin-biotin system was prepared for possible design of nanospheres with targeting properties. Studies of drug release from polymeric systems containing multiblock copolymers and studies of polymer degradation were also performed.

Original language	English
Pages (from-to)	1019-1025
Number of pages	7
Journal	Macromolecular Bioscience
Volume	6
Issue number	12
DOIs	https://doi.org/10.1002/mabi.200600165
State	Published - 8 Dec 2006

Keywords

Avidin-biolin system
Biodegradable polymers
Biopolymers
Multiblock copolymers

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomaterials
Polymers and Plastics
Materials Chemistry

Access to Document

10.1002/mabi.200600165

Cite this

@article{35ced9ed02b24f88984c682075ff48a8,

title = "PEG-PLA block copolymer as potential drug carrier: Preparation and characterization",

abstract = "Diblock and multiblock copolymers composed of a poly(D,L-lactide) (PLA) or poly(trimethylene carbonate) (PTMC) core with a hydrophilic chain of poly(ethylene glycol) (PEG) were prepared. These copolymers, in which the core is connected to PEG through a polyfunctional molecule such as citric, mucic, or tartaric acid, may be used to form nanoparticles for drug delivery applications. Branched copolymers were prepared by direct amidation between the polyfunctional acid and methoxy PEGamine, followed by ring-opening polymerization of lactide or trimethyl carbonate to form the PLA and PTMC block copolymers. In addition, a complex multiblock copolymer of biotin-PEG- poly[lactic-co-(glycolic acid)] (PLGA) for application in an avidin-biotin system was prepared for possible design of nanospheres with targeting properties. Studies of drug release from polymeric systems containing multiblock copolymers and studies of polymer degradation were also performed.",

keywords = "Avidin-biolin system, Biodegradable polymers, Biopolymers, Multiblock copolymers",

author = "Shimon Ben-Shabat and Neeraj Kumar and Domb, {Abraham J.}",

year = "2006",

month = dec,

day = "8",

doi = "10.1002/mabi.200600165",

language = "English",

volume = "6",

pages = "1019--1025",

journal = "Macromolecular Bioscience",

issn = "1616-5187",

publisher = "Wiley-VCH Verlag",

number = "12",

}

TY - JOUR

T1 - PEG-PLA block copolymer as potential drug carrier

T2 - Preparation and characterization

AU - Ben-Shabat, Shimon

AU - Kumar, Neeraj

AU - Domb, Abraham J.

PY - 2006/12/8

Y1 - 2006/12/8

N2 - Diblock and multiblock copolymers composed of a poly(D,L-lactide) (PLA) or poly(trimethylene carbonate) (PTMC) core with a hydrophilic chain of poly(ethylene glycol) (PEG) were prepared. These copolymers, in which the core is connected to PEG through a polyfunctional molecule such as citric, mucic, or tartaric acid, may be used to form nanoparticles for drug delivery applications. Branched copolymers were prepared by direct amidation between the polyfunctional acid and methoxy PEGamine, followed by ring-opening polymerization of lactide or trimethyl carbonate to form the PLA and PTMC block copolymers. In addition, a complex multiblock copolymer of biotin-PEG- poly[lactic-co-(glycolic acid)] (PLGA) for application in an avidin-biotin system was prepared for possible design of nanospheres with targeting properties. Studies of drug release from polymeric systems containing multiblock copolymers and studies of polymer degradation were also performed.

AB - Diblock and multiblock copolymers composed of a poly(D,L-lactide) (PLA) or poly(trimethylene carbonate) (PTMC) core with a hydrophilic chain of poly(ethylene glycol) (PEG) were prepared. These copolymers, in which the core is connected to PEG through a polyfunctional molecule such as citric, mucic, or tartaric acid, may be used to form nanoparticles for drug delivery applications. Branched copolymers were prepared by direct amidation between the polyfunctional acid and methoxy PEGamine, followed by ring-opening polymerization of lactide or trimethyl carbonate to form the PLA and PTMC block copolymers. In addition, a complex multiblock copolymer of biotin-PEG- poly[lactic-co-(glycolic acid)] (PLGA) for application in an avidin-biotin system was prepared for possible design of nanospheres with targeting properties. Studies of drug release from polymeric systems containing multiblock copolymers and studies of polymer degradation were also performed.

KW - Avidin-biolin system

KW - Biodegradable polymers

KW - Biopolymers

KW - Multiblock copolymers

UR - http://www.scopus.com/inward/record.url?scp=33845930266&partnerID=8YFLogxK

U2 - 10.1002/mabi.200600165

DO - 10.1002/mabi.200600165

M3 - Article

AN - SCOPUS:33845930266

SN - 1616-5187

VL - 6

SP - 1019

EP - 1025

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

IS - 12

ER -

PEG-PLA block copolymer as potential drug carrier: Preparation and characterization

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this