PEG-PLA block copolymer as potential drug carrier: Preparation and characterization

Shimon Ben-Shabat, Neeraj Kumar, Abraham J. Domb

    Research output: Contribution to journalArticlepeer-review

    52 Scopus citations

    Abstract

    Diblock and multiblock copolymers composed of a poly(D,L-lactide) (PLA) or poly(trimethylene carbonate) (PTMC) core with a hydrophilic chain of poly(ethylene glycol) (PEG) were prepared. These copolymers, in which the core is connected to PEG through a polyfunctional molecule such as citric, mucic, or tartaric acid, may be used to form nanoparticles for drug delivery applications. Branched copolymers were prepared by direct amidation between the polyfunctional acid and methoxy PEGamine, followed by ring-opening polymerization of lactide or trimethyl carbonate to form the PLA and PTMC block copolymers. In addition, a complex multiblock copolymer of biotin-PEG- poly[lactic-co-(glycolic acid)] (PLGA) for application in an avidin-biotin system was prepared for possible design of nanospheres with targeting properties. Studies of drug release from polymeric systems containing multiblock copolymers and studies of polymer degradation were also performed.

    Original languageEnglish
    Pages (from-to)1019-1025
    Number of pages7
    JournalMacromolecular Bioscience
    Volume6
    Issue number12
    DOIs
    StatePublished - 8 Dec 2006

    Keywords

    • Avidin-biolin system
    • Biodegradable polymers
    • Biopolymers
    • Multiblock copolymers

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