Pemphigus and depression comorbidity: A case control study

Yonit Wohl, Jacob Mashiah, Ana Kutz, Smail Hadj-Rabia, Arnon D. Cohen

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background: While quality of life can be significantly affected in pemphigus patients, few studies have systematically investigated the co-morbidity of psychiatric disorders in these patients. Objective: To assess the association between pemphigus and depression comorbidity, using the computerized medical database of Israel’s largest health maintenance organization. Methods: In a case-control study, co-morbidities of adult pemphigus patients retrieved from the database of a large healthcare organization from 1998 to 2010 were compared with ageand gender-matched controls from the same database. The main outcome measure was the prevalence of co-morbid psychiatric disorders (anxiety, psychosis, schizophrenia and depression) in pemphigus patients and controls. The study included 255 pemphigus patients (157 women (62%) and 98 (38%) men) and 509 controls (313 women (62%) and 196 (38%) men) aged 20 years and older (a ratio of 3:2 in both groups). Mean age was 63.5 ± 15.7 years in the pemphigus group and 63.2 ± 15.7 years in the control group. Results: Depression was the only psychiatric disorder significantly increased among pemphigus patients compared with controls. Alcohol abuse and smoking did not differ between groups. Depression was over-represented in a large population of pemphigus patients, indicating the disorder as a possible significant co-morbidity. After controlling for confounders including age, gender, and duration of corticosteroid therapy, the association with depression persisted (OR = 1.19, 95% CI: 1.12-1.27), p<0.001). Conclusion: The increased prevalence of depressive morbidity, especially in the presence of commonly prescribed corticosteroid treatment, emphasizes the need for psychiatric assessment and intervention in these patients.

Original languageEnglish
Pages (from-to)602-605
Number of pages4
JournalEuropean Journal of Dermatology
Issue number6
StatePublished - 1 Nov 2015


  • Corticoid therapy
  • Depression
  • Pemphigus

ASJC Scopus subject areas

  • Dermatology


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