Pentacyclic triterpenoids from Embelia schimperi

Alex K. Machocho, Paul C. Kiprono, Sarina Grinberg, Shmuel Bittner

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31 Scopus citations

Abstract

Five oleanane-type pentacyclic triterpenoids were isolated by chromatographic separation of a chloroform extract of the stem bark of Embelia schimperi. Three of these compounds have a methyleneoxy bridge. Two compounds, embelinone and schimperinone, are reported here for the first time from a natural source (they have been synthesized previously during chemical transformations). Their structures were determined by spectroscopic techniques, among which 2-D NMR was useful for complete characterization. Three of the triterpenoids exhibited mild antibacterial properties against the gram-positive bacterial strain Rhodococcus sp.

Original languageEnglish
Pages (from-to)573-577
Number of pages5
JournalPhytochemistry
Volume62
Issue number4
DOIs
StatePublished - 1 Feb 2003

Keywords

  • Aegicerin
  • Antibacterial activity
  • Embelia schimperi
  • Embelinone
  • Myrsinaceae
  • Pentacyclic triterpenoids
  • Primulagenin A
  • Protoprimulagenin A
  • Schimperinone

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