Peptide based hydrogels for cancer drug release: Modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating d-amino acid residue(s)

Kingshuk Basu; Abhishek Baral; Shibaji Basak; Ashkan Dehsorkhi; Jayanta Nanda; Debmalya Bhunia; Surajit Ghosh; Valeria Castelletto; Ian W. Hamley; Arindam Banerjee

doi:10.1039/c6cc01744d

Peptide based hydrogels for cancer drug release: Modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating d-amino acid residue(s)

Kingshuk Basu
, Abhishek Baral
, Shibaji Basak
, Ashkan Dehsorkhi
, Jayanta Nanda
, Debmalya Bhunia
, Surajit Ghosh
, Valeria Castelletto
, Ian W. Hamley
, Arindam Banerjee

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

Synthetic tripeptide based noncytotoxic hydrogelators have been discovered for releasing an anticancer drug at physiological pH and temparature. Interestingly, gel stiffness, drug release capacity and proteolytic stability of these hydrogels have been successfully modulated by incorporating d-amino acid residues, indicating their potential use for drug delivery in the future.

Original language	English
Pages (from-to)	5045-5048
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	28
DOIs	https://doi.org/10.1039/c6cc01744d
State	Published - 11 Apr 2016

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c6cc01744d

Cite this

Basu, K., Baral, A., Basak, S., Dehsorkhi, A., Nanda, J., Bhunia, D., Ghosh, S., Castelletto, V., Hamley, I. W., & Banerjee, A. (2016). Peptide based hydrogels for cancer drug release: Modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating d-amino acid residue(s). Chemical Communications, 52(28), 5045-5048. https://doi.org/10.1039/c6cc01744d

@article{fb23caf122f34b2981469103cfe93336,

title = "Peptide based hydrogels for cancer drug release: Modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating d-amino acid residue(s)",

abstract = "Synthetic tripeptide based noncytotoxic hydrogelators have been discovered for releasing an anticancer drug at physiological pH and temparature. Interestingly, gel stiffness, drug release capacity and proteolytic stability of these hydrogels have been successfully modulated by incorporating d-amino acid residues, indicating their potential use for drug delivery in the future.",

author = "Kingshuk Basu and Abhishek Baral and Shibaji Basak and Ashkan Dehsorkhi and Jayanta Nanda and Debmalya Bhunia and Surajit Ghosh and Valeria Castelletto and Hamley, \{Ian W.\} and Arindam Banerjee",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

month = apr,

day = "11",

doi = "10.1039/c6cc01744d",

language = "English",

volume = "52",

pages = "5045--5048",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "28",

}

Basu, K, Baral, A, Basak, S, Dehsorkhi, A, Nanda, J, Bhunia, D, Ghosh, S, Castelletto, V, Hamley, IW & Banerjee, A 2016, 'Peptide based hydrogels for cancer drug release: Modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating d-amino acid residue(s)', Chemical Communications, vol. 52, no. 28, pp. 5045-5048. https://doi.org/10.1039/c6cc01744d

TY - JOUR

T1 - Peptide based hydrogels for cancer drug release

T2 - Modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating d-amino acid residue(s)

AU - Basu, Kingshuk

AU - Baral, Abhishek

AU - Basak, Shibaji

AU - Dehsorkhi, Ashkan

AU - Nanda, Jayanta

AU - Bhunia, Debmalya

AU - Ghosh, Surajit

AU - Castelletto, Valeria

AU - Hamley, Ian W.

AU - Banerjee, Arindam

PY - 2016/4/11

Y1 - 2016/4/11

N2 - Synthetic tripeptide based noncytotoxic hydrogelators have been discovered for releasing an anticancer drug at physiological pH and temparature. Interestingly, gel stiffness, drug release capacity and proteolytic stability of these hydrogels have been successfully modulated by incorporating d-amino acid residues, indicating their potential use for drug delivery in the future.

AB - Synthetic tripeptide based noncytotoxic hydrogelators have been discovered for releasing an anticancer drug at physiological pH and temparature. Interestingly, gel stiffness, drug release capacity and proteolytic stability of these hydrogels have been successfully modulated by incorporating d-amino acid residues, indicating their potential use for drug delivery in the future.

UR - https://www.scopus.com/pages/publications/84962407495

U2 - 10.1039/c6cc01744d

DO - 10.1039/c6cc01744d

M3 - Article

C2 - 26987440

AN - SCOPUS:84962407495

SN - 1359-7345

VL - 52

SP - 5045

EP - 5048

JO - Chemical Communications

JF - Chemical Communications

IS - 28

ER -

Peptide based hydrogels for cancer drug release: Modulation of stiffness, drug release and proteolytic stability of hydrogels by incorporating d-amino acid residue(s)

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this