Peptide-Based Low Molecular Weight Photosensitive Supramolecular Gelators

Bapan Pramanik, Sahnawaz Ahmed

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Over the last couple of decades, stimuli-responsive supramolecular gels comprising synthetic short peptides as building blocks have been explored for various biological and material applications. Though a wide range of stimuli has been tested depending on the structure of the peptides, light as a stimulus has attracted extensive attention due to its non-invasive, non-contaminant, and remotely controllable nature, precise spatial and temporal resolution, and wavelength tunability. The integration of molecular photo-switch and low-molecular-weight synthetic peptides may thus provide access to supramolecular self-assembled systems, notably supramolecular gels, which may be used to create dynamic, light-responsive “smart” materials with a variety of structures and functions. This short review summarizes the recent advancement in the area of light-sensitive peptide gelation. At first, a glimpse of commonly used molecular photo-switches is given, followed by a detailed description of their incorporation into peptide sequences to design light-responsive peptide gels and the mechanism of their action. Finally, the challenges and future perspectives for developing next-generation photo-responsive gels and materials are outlined.

Original languageEnglish
Article number533
Issue number9
StatePublished - 1 Sep 2022


  • arylazopyrozoles
  • azobenzene
  • gel
  • peptide
  • spiropyran
  • stimuli responsive
  • trans-cis isomerization

ASJC Scopus subject areas

  • Bioengineering
  • Polymers and Plastics
  • Biomaterials
  • Organic Chemistry


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