Peptide-Polypeptide Co-Assembled Nanoparticles for Drug Delivery

Hanna Rapaport (Inventor), Ifat Cohen (Inventor)

Research output: Patent

Abstract

The present invention relates to co-assembled nanoparticles comprising at least one polypeptide comprising a polyanion; and at least one amphiphilic peptide capable of forming a β-sheet structure, a derivative or a salt thereof, the amphiphilic peptide comprising at least 2 pairs of alternating hydrophobic/hydrophilic amino acid residues, wherein the hydrophilic amino acid residue is positively charged, and methods of preparation of said nanoparticles. There are further provided pharmaceutical compositions comprising the co-assembled nanoparticles and a pharmaceutically active ingredient, dissolved, entrapped, encapsulated or attached to the co- assembled nanoparticles. The present invention further provides therapeutic uses of said pharmaceutical compositions.
Original languageEnglish GB
Patent numberEP3142964A4
IPCA61K9/0019
Filing date15/05/15
StatePublished - 1 Oct 2020

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