Percutaneous core needle biopsy vs. Fine needle aspiration in diagnosing benign lung lesions

Joel Greif, Sylvia Marmor, Yehuda Schwarz, Alexander N. Staroselsky

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


OBJECTIVE: To determine the diagnostic value of percutaneous core needle biopsy (PCNB) in comparison with fine needle aspiration (FNA) in patients with benign pulmonary lesions. STUDY DESIGN: A retrospective review was undertaken of computed tomography-guided PCNBs and FNAs performed between 1988 and 1997. Both FNA and PCNB biopsies were carried out sequentially at the same visit in every patient. RESULTS: A specific benign diagnosis was made in 10/60 cases (16.7%) by FNA and in 49/60 (81.7%) by PCNB. PCNB findings resulted in significant modification of the diagnosis established by FNA. The only significant complication encountered was pneumothorax, at a rate of 11.7%, which is compatible with that reported in the literature for complications induced by FNA alone. CONCLUSION: Radiologically guided PCNB is a safe procedure, can provide sufficient histologic material for a specific diagnosis of peripheral lung disease and can avoid more-invasive surgical procedures in many cases. Our experience demonstrated that the histologic analysis provided by PCNB can greatly increase the diagnostic accuracy in benign pulmonary diseases as compared with the yield of FNA.

Original languageEnglish
Pages (from-to)756-760
Number of pages5
JournalActa Cytologica
Issue number5
StatePublished - 1 Jan 1999
Externally publishedYes


  • Aspiration biopsy
  • Biopsy
  • Lung diseases
  • Needle
  • Percutaneous core needle biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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