Perinatal outcome in cases of latent syphilis during pregnancy

Yonit Krakauer, Gali Pariente, Ruslan Sergienko, Arnon Wiznitzer, Eyal Sheiner

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Objective: To investigate factors associated with latent syphilis and pregnancy outcome among women with latent syphilis. Methods: A retrospective population-based study was conducted to compare all pregnancies among women with and without latent syphilis at Soroka University Medical Center, Be'er-Sheva, Israel, between 1988 and 2010. Stratified analysis using a multiple logistic regression model was performed to control for confounders. Results: Of the 219 656 deliveries during the study period, 159 (0.1%) involved women with latent syphilis. Multivariate analysis with backward elimination revealed the following conditions to be significantly associated with latent syphilis: fetal growth restriction (odds ratio [OR] 2.20; 95% confidence interval [CI], 1.07-4.49; P = 0.03); drug abuse (OR 9.95; 95% CI, 1.31-75.46; P = 0.02); tobacco use (OR 3.35; 95% CI, 1.74-6.45; P < 0.05); and Jewish (vs Bedouin) ethnicity (OR 4.05; 95% CI, 2.65-6.20; P < 0.05). Conclusion: Women with latent syphilis are at risk for adverse maternal and perinatal outcomes, including fetal growth restriction. Careful surveillance of these high-risk pregnancies should be considered.

Original languageEnglish
Pages (from-to)15-17
Number of pages3
JournalInternational Journal of Gynecology and Obstetrics
Issue number1
StatePublished - 1 Jan 2012
Externally publishedYes


  • Fetal growth restriction
  • Latent syphilis
  • Pregnancy complications

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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