Perinatal outcome of women with known celiac disease

Objective
Tuberculosis is a rare infectious disease in the western world. The purpose of the current study was to evaluate perinatal outcome of women with tuberculosis.

Study Design
In a population-based cohort study, perinatal outcome of singleton deliveries of women with tuberculosis was evaluated and compared to singleton deliveries of women without tuberculosis. Deliveries occurred between the years 1991 and 2017 in a tertiary medical center. Generalized estimation equation (GEE) model were used to control for confounders.

Results
During the study period 243,682 deliveries were included, of which 46 (0.018%) occurred in women with tuberculosis. Maternal tuberculosis was found to be associated with several pregnancy complications including placental abruption, cesarean delivery and very low birth weight (VLBW; Table 1). Using GEE model, controlling for gestational age, maternal tuberculosis was found to be independently associated with placental abruption, cesarean deliveries and VLBW (Table 2).

Conclusion
Maternal tuberculosis is independently associated with adverse perinatal outcomes including placental abruption, cesarean deliveries and VLBW. Careful surveillance should be offered to women with tuberculosis in order to prevent avoidable pregnancy complications.