Perinatal outcomes in condyloma acuminata pregnancies

Objective: To investigate pregnancy outcome in patients with condyloma acuminata. Methods: A retrospective cohort study comparing pregnancy outcome of women with and without condyloma acuminata was performed. A sub-group analysis was performed between patients with localized disease (n = 40), extended disease (n = 25) and no condyloma acuminata (n = 227,202). Results: Using a multivariate logistic regression model, condyloma acuminata was significantly associated with cesarean delivery (OR = 3.4; 95% CI 1.9-5.8; P < 0.001), nulliparity (OR = 4.8; 95% CI 2.6-9.0; P < 0.001), and Jewish ethnicity (vs. Bedouin Arabs; OR = 2.3; 95% CI 1.3-4.1; P < 0.001). A significant linear association was found between the three subgroup (extended condyloma, localized condyloma and no condyloma) and cesarean delivery (40.0% in the extended disease vs. 32.5% in the localized disease vs. 13.0% in the comparison group P < 0.001). No significant differences were noted between the groups in terms of perinatal outcomes, such as low Apgar score (<7) at 1 min (4.2 vs. 1.6%; P = 0.298) and 5 min (0.6 vs. 0.0% P = 0.534) and perinatal mortality (1.4 vs. 1.5% P = 0.912). Conclusions: Women with condyloma acuminata are at an increased risk for cesarean delivery, while the risk for cesarean delivery is higher for pregnancies with extended when compared with localized disease. Nevertheless, condyloma acuminata is not associated with adverse perinatal outcome.