Perinatal Vasoconstrictive Renal Insufficiency Associated with Maternal Nimesulide Use

Daniel Landau; Ilan Shelef; Hanna Polacheck; M. J. Pharm; Kyla Marks; Gershon Holcberg

doi:10.1055/s-1999-6810

Perinatal Vasoconstrictive Renal Insufficiency Associated with Maternal Nimesulide Use

Daniel Landau, Ilan Shelef, Hanna Polacheck, M. J. Pharm, Kyla Marks, Gershon Holcberg

Research output: Contribution to journal › Article › peer-review

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Abstract

A full-term newborn developed oliguric renal failure at 24 hr of life, which persisted for several days. Her mother ingested therapeutic doses of nimesulide, a nonsteroidal anti-inflammatory (cyclo-oxygenase-2 inhibitor) drug, during the last 2 weeks of pregnancy. She was found at delivery to have developed oligohydramnion, esophagitis, and a bleeding peptic ulcer. The infant's fractional excretion of sodium was very low (0.5%) pointing for a severe vasoconstrictive mechanism involved. Renal sonogram showed hyperechogenic medullary papillae, which resolved during convalescence. This case emphasizes the importance of renal prostagandins in the control of vascular tone and sodium homeostasis. This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.

Original language	English
Pages (from-to)	441-444
Number of pages	4
Journal	American Journal of Perinatology
DOIs	https://doi.org/10.1055/s-1999-6810
State	Published - 1 Jan 1999

Keywords

Renal failure, acute
nimesulide
nonsteroidal anti-inflammatory drugs

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1055/s-1999-6810

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title = "Perinatal Vasoconstrictive Renal Insufficiency Associated with Maternal Nimesulide Use",

abstract = "A full-term newborn developed oliguric renal failure at 24 hr of life, which persisted for several days. Her mother ingested therapeutic doses of nimesulide, a nonsteroidal anti-inflammatory (cyclo-oxygenase-2 inhibitor) drug, during the last 2 weeks of pregnancy. She was found at delivery to have developed oligohydramnion, esophagitis, and a bleeding peptic ulcer. The infant's fractional excretion of sodium was very low (0.5%) pointing for a severe vasoconstrictive mechanism involved. Renal sonogram showed hyperechogenic medullary papillae, which resolved during convalescence. This case emphasizes the importance of renal prostagandins in the control of vascular tone and sodium homeostasis. This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.",

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doi = "10.1055/s-1999-6810",

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AU - Landau, Daniel

AU - Shelef, Ilan

AU - Polacheck, Hanna

AU - Pharm, M. J.

AU - Marks, Kyla

AU - Holcberg, Gershon

PY - 1999/1/1

Y1 - 1999/1/1

N2 - A full-term newborn developed oliguric renal failure at 24 hr of life, which persisted for several days. Her mother ingested therapeutic doses of nimesulide, a nonsteroidal anti-inflammatory (cyclo-oxygenase-2 inhibitor) drug, during the last 2 weeks of pregnancy. She was found at delivery to have developed oligohydramnion, esophagitis, and a bleeding peptic ulcer. The infant's fractional excretion of sodium was very low (0.5%) pointing for a severe vasoconstrictive mechanism involved. Renal sonogram showed hyperechogenic medullary papillae, which resolved during convalescence. This case emphasizes the importance of renal prostagandins in the control of vascular tone and sodium homeostasis. This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.

AB - A full-term newborn developed oliguric renal failure at 24 hr of life, which persisted for several days. Her mother ingested therapeutic doses of nimesulide, a nonsteroidal anti-inflammatory (cyclo-oxygenase-2 inhibitor) drug, during the last 2 weeks of pregnancy. She was found at delivery to have developed oligohydramnion, esophagitis, and a bleeding peptic ulcer. The infant's fractional excretion of sodium was very low (0.5%) pointing for a severe vasoconstrictive mechanism involved. Renal sonogram showed hyperechogenic medullary papillae, which resolved during convalescence. This case emphasizes the importance of renal prostagandins in the control of vascular tone and sodium homeostasis. This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.

KW - Renal failure, acute

KW - nimesulide

KW - nonsteroidal anti-inflammatory drugs

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JF - American Journal of Perinatology

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Perinatal Vasoconstrictive Renal Insufficiency Associated with Maternal Nimesulide Use

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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