Persistence of a positive test for IgM antibodies to hepatitis A virus in late convalescent sera

E. Sikuler, A. Keynan, N. Hanuka, G. Zagron-Bachir, I. Sarov

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12 Scopus citations

Abstract

We had the opportunity to carry out a long-term follow up of 15 patients with viral hepatitis Type A. The serum IgM response to hepatitis A virus (HAV) was investigated with a commercially available kit (HAVAB-M). IgM antibodies were detected in all specimens collected during the acute phase of the disease and during early convalescence (first 3 months). However, there was a clear decrease in the ample-to-cutoffratio (s/co ratio) after the first 2 months. Serum samples were available from six patients 30 to 32 months after onset of illness. Two of these were positive for IgM anti-HAV, but the s/co ratios were low. These results point to the need for careful evaluation of the diagnosis of acute or recent viral hepatitis Type A when low s/co ratios are obtained.

Original languageEnglish
Pages (from-to)193-195
Number of pages3
JournalIsrael Journal of Medical Sciences
Volume23
Issue number3
StatePublished - 28 Aug 1987
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering

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